584-27-0

Basic information

• Product Name: 4,4-DIMETHYL ITACONIC ACID
• Synonyms: 2-Isopropylidenebutanedioic acid;4,4-DIMETHYL ITACONIC ACID;ISOPROPYLIDENE SUCCINIC ACID;TIMTEC-BB SBB003996
• CAS NO: 584-27-0
• Molecular Formula: C₇H₁₀O₄
• Molecular Weight: 158.15
• Mol File: 584-27-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 160.5°C
• Boiling Point: 203.22°C (rough estimate)
• Appearance: /
• Density: 1.1229 (rough estimate)
• Refractive Index: 1.4610 (estimate)
• CAS DataBase Reference: 4,4-DIMETHYL ITACONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-DIMETHYL ITACONIC ACID(584-27-0)
• EPA Substance Registry System: 4,4-DIMETHYL ITACONIC ACID(584-27-0)

Safety Data

• Hazardous Substances Data: 584-27-0(Hazardous Substances Data)

Upstream product

• 87989-21-7 isopropenyl-succinic acid 
• 42103-98-0 diethyl isopropylidenesuccinate 
• 107099-97-8 3-methyl-but-3-ene-1,1,2-tricarboxylic acid 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 20201-24-5 ethyl 3-methyl-2-oxobutanoate 
• 74222-68-7 dihydro-3-(methylethylidene)-2,5-furandione 
• 7732-18-5 water 
• 64198-15-8 3-isopropylfuran-2,5-dione 
• 141-52-6 sodium ethanolate 
• 67-64-1 acetone 
• 1642-61-1 (α-nitro-isopropyl)-succinic acid dimethyl ester 
• 2088-01-9 diethyl 2-(1-methyl-1-nitroethyl)butanedioate 
• 13017-67-9 3,3-dimethylcyclopropane-1,1,2,2-tetracarbonitrile 
• 6934-75-4 Isopropylidenbernsteinsaeure-dimethylester 

Downstream Products

• 42103-98-0 diethyl isopropylidenesuccinate 
• 79-91-4 terebic acid 
• 3123-97-5 dihydro-5,5-dimethyl-2(3H)-furanone 
• 328-42-7 Oxalacetic acid 
• 144-62-7 oxalic acid 
• 64-19-7 acetic acid 
• 67-64-1 acetone 
• 151927-79-6 2-(2-(benzyloxy)-2-oxoethyl)-3-methylbut-2-enoic acid 
• 151928-18-6 3-[2-(Benzyloxycarbamoyl-methyl)-3-methyl-butyrylamino]-propionic acid 
• 164364-47-0 N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-β-alanine 1,1-dimethylethyl ester 
• 164364-46-9 N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-asparginamide 
• 164364-60-7 N-<2-(methylethyl)-1,4-dioxo-4-<(phenylmethoxy)amino>butyl>-β-alanine 1,1-dimethylethyl ester 
• 151927-81-0 [2-(1-Methylethyl)-1,4-dioxo-4-[(phenylmethoxy)amino]butyl]-L-asparagine 
• 164364-45-8 N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-aspargine 1,1-dimethylethylester 

Relevant articles and documents

Novel fatty acid synthase (FAS) inhibitors: Design, synthesis, biological evaluation, and molecular docking studies

Several novel series of C75 derivatives were synthesized and evaluated for their FAS inhibitory activities. The results showed compound 4-methylene-2-octyl-5-oxo-tetrahydro-thiophene-3-carboxylic acid (1c) had more effective FAS inhibitory (IC50 was 2.56 μM and T.I. was 9.26) and potent anti-tumor activities on HL60 and Hela cells in vitro (IC50 were 5.38 μM and 46.10 μM, respectively).

Process for preparing alkylidene substituted succinic acid esters

A process for the preparation of alkylidene substituted succinates comprising a step (a) in which is carried out the reaction of a carbonilic compound, a succinic and a base in a reaction medium and a step (b) in which the alkylidene substituted product obtained in (a) is esterified, characterized in that the succinic ester is used in a molar amount substantially equal to, or lower than, the amount of compound carbonilic compound, (ii) the base is used in a molar amount substantially equal to the succinic ester and is selected from metal hydrides and metal and alkoxides, and (iii) the reaction medium comprises an aprotic liquid medium or a protic liquid medium having a Ka, measured in water, lower than that of iPrOH.

Inhibitors of the conversion of big endothelin to endothelin

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