59146-56-4Relevant articles and documents
LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS
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Paragraph 00372, (2022/03/02)
Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.
INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE
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Paragraph 00243, (2021/10/02)
Bifunctional compounds, which find utility as modulators of leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
Fluorene-containing polyhedral oligomericsilsesquioxanes modified hyperbranched polymer for white light-emitting diodes with ultra-high color rendering index of 96
Wang, Mixue,Wei, Xiaozhen,Zhang, Weixuan,Zhao, Haocheng,Wu, Yuling,Miao, Yanqin,Wang, Hua,Xu, Bingshe
, (2021/04/02)
In this work, a series of hyperbranched white-emitting conjugated polymers were synthesized with polyfluorene (PF) as the branches and three-dimensional-structured spiro[3.3]heptane-2,6-dispirofluorene (SDF) as the conjugated branching point by one-pot Suzuki polycondensation, where 4,7-dithienyl-2,1,3-benzothiadiazole (DBT) as orange-light emitting unit and fluorene-containing polyhedral oligomericsilsesquioxanes (POSSs) as conjugated linking monomer were introduced into the backbones to obtain white-light emission. The influence mechanism of POSSs for hyperbranched white-emitting polymers was explored by adjusting the feeding ratios of fluorene-containing POSSs (from 1 to 20 ?mol%). The results indicated that the synthesized polymers still maintained the high thermal stabilities, and exhibited the improved amorphous film morphology and hydrophobicity, which were beneficial for obtaining optimized interface between the aqueous hole transport layer Poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT: PSS) layer and polymer light-emitting layer in device fabrication. As a consequence, all of the fabricated devices with the hyperbranched polymers as light-emitting layers realized white light-emission, and the optimized device exhibite good electroluminescent (EL) performance with Commission Internationale de l'Eclairage (CIE) coordinates at (0.32, 0.33) and maximum color rendering index (CRI) of 96. The fluorene-containing POSSs modified hyperbranched copolymers with broad full width at half maximum (>284 ?nm) are attractive candidates for sunlight-style white polymer light-emitting diodes.