60-01-5Relevant articles and documents
Efficient and regioselective ring-opening of epoxides with carboxylic acid catalyzed by graphite oxide
Mirza-Aghayan, Maryam,Tavana, Mahdieh Molaee,Niazi, Elaheh Golam Alipour,Boukherroub, Rabah
, p. 532 - 538 (2020/07/17)
An efficient, simple and regioselective ring-opening reaction of epoxides with various carboxylic acids under metal-free conditions is reported. The ring-opening of epoxides takes place in the presence of graphite oxide as an efficient and available catalyst to produce the corresponding 2-hydroxy monoester and 1,2-diester derivatives in good yields. Regioselective attack of the nucleo-phile, short reaction times, metal-free conditions and reusability of catalyst are among the advantages of the present protocol.
Method for synthesizing butyrin
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Paragraph 0017-0019, (2017/09/08)
The invention provides a method for synthesizing butyrin. According to the method, butyric acid, glycerinum, a catalyst and a solid dehydrating agent are subjected to an esterification reaction under the heating condition, after the reaction is finished, filtration is conducted, a sodium hydroxide solution is dropwise added to the filtrate until the filtrate is neutral, then still standing and layering are conducted, the supernatant oil phase is taken to pass through an anhydrous sodium sulfate dry column, and the butyrin product is obtained. According to the method, it is avoided that an organic solvent serves as a water-carrying agent, the evaporation cost is decreased, the potential production safety hazard is reduced, pollution to the environment is avoided, and the synthesis technology is environmentally friendlier and safer; meanwhile, it is avoided that the organic solvent possibly remains in the product to cause potential safety hazard when the product is applied to feed-products; in addition, the esterification reaction is more efficient by the addition of the solid dehydrating agent, the reaction time is shortened and the reaction conversion ratio is increased.
A method for preparing butyrin
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Paragraph 0025-0026, (2017/03/17)
The invention provides a method for preparing tributyrin. The method comprises the following steps: reacting glycerinum with butyryl chloride by taking organic alkali as a acid-binding agent, thereby obtaining a mixture containing tributyrin, wherein the mole ratio of the three materials, namely, glycerinum, butyryl chloride and organic alkali, is 1:(3-3.3):3.3. The method further comprises the following steps: extracting a mixture containing tributyrin by using water, collecting an organic phase, and performing reduction vaporization to remove a solvent in the organic phase, thereby obtaining tributyrin. In the method, the mole ratio of butyryl chloride to glycerinum is kept at (3-3.3):1 during reaction, and massive over amount is not needed. In addition, after the reaction is completed, residual trace butyryl chloride can be hydrated into butyric acid and hydrochloric acid in the following water washing process and can be carried away by a water phase together with residual glycerinum, thus a purpose that butyryl chloride is separated from a target object is achieved.