612-20-4

Basic information

• Product Name: 2-(hydroxymethyl)benzoic acid
• Synonyms: o-(Hydroxymethyl)benzoic acid;2-methylolbenzoic acid;Benzoic acid, 2-(hydroxyMethyl)-;Butylphthalide Impurity 5
• CAS NO: 612-20-4
• Molecular Formula: C₈H₈O₃
• Molecular Weight: 152.15
• EINECS: 210-298-6
• Mol File: 612-20-4.mol
• Article Data: 25

Chemical Properties

• Melting Point: 139.5-140.5 °C
• Boiling Point: 333.9°Cat760mmHg
• Flash Point: 169.9°C
• Appearance: /
• Density: 1.314g/cm³
• Vapor Pressure: 5.26E-05mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.84±0.10(Predicted)
• CAS DataBase Reference: 2-(hydroxymethyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(hydroxymethyl)benzoic acid(612-20-4)
• EPA Substance Registry System: 2-(hydroxymethyl)benzoic acid(612-20-4)

Safety Data

• Hazardous Substances Data: 612-20-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 5147, 1988 DOI: 10.1021/jo00256a045

InChI:InChI=1/C8H8O3/c9-5-6-3-1-2-4-7(6)8(10)11/h1-4,9H,5H2,(H,10,11)

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 4376-18-5 Monomethyl phthalate 
• 79644-73-8 phthalidyl-glyoxylic acid ethyl ester 
• 20643-65-6 3-(4-nitrophenyl)isobenzofuran-1(3H)-one 
• 124-38-9 carbon dioxide 
• 5159-41-1 2-iodobenzyl alcohol 
• 5693-27-6 isochroman-1,4-dione 
• 95-47-6 o-xylene 
• 18982-54-2 o-bromobenzyl alcohol 
• 693-04-9 butyl magnesium bromide 
• 119-67-5 o-carboxybenzaldehyde 
• 612-14-6 phthalyl alcohol 
• 136918-14-4 phthalimide 
• 50-00-0 formaldehyd 

Downstream Products

• 163152-10-1 2-(chloroacetoxymethyl)benzoic acid 
• 119-67-5 o-carboxybenzaldehyde 
• 588702-39-0 n-butyl 2-hydroxymethylbenzoate 
• 87-41-2 2-benzofuran-1(3H)-one 
• 132286-88-5 2-(((tert-butyldiphenylsilyl)oxy)methyl)benzoic acid 
• 129452-86-4 2-<(tert-butyldiphenylsilyloxy)methyl>benzoyl chloride 
• 942-57-4 methyl 2-(methoxymethyl)benzoate 
• 35461-75-7 2-Acetoxymethyl-benzoesaeure 

Relevant articles and documents

Milled Dry Ice as a C1 Source for the Carboxylation of Aryl Halides

The use of carbon dioxide as a C1 chemical feedstock remains an active field of research. Here we showcase the use of milled dry ice as a method to promote the availability of CO 2in a reaction solution, permitting practical synthesis of arylcarboxylic acids. Notably, the use of milled dry ice produces marked increases in yields relative to those obtained with gaseous CO 2, as previously reported in the literature.

MODULATORS OF HEMOGLOBIN

The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of hemoglobin, and methods for their use in treating disorders mediated by hemoglobin.

A chloroacetate based ratiometric fluorescent probe for cysteine detection in biosystems

The specific detection of cysteine (Cys) over homocysteine (Hcy), glutathione (GSH) and other amino acids is of great significance for studying its biological functions as well as for the diagnosis of related diseases. Chloroacetyl group was often used as a reaction site for cysteine fluorescent probes for its sensitivity and selectivity. However, high background fluorescence and low stability are common problems encountered by such probes. Here, four chloroacetyl group based fluorescent probes (C1, C2, C3, and H4) was synthesized for a comparative study. We found that the inefficient quenching ability of chloroacetyl group turned into an advantage when connected with a ratiometric fluorophore. With the modification of chloroacetyl group, probe H4 displayed excellent ratiometric property and great selectivity for Cys, the stability was also improved. Additionally, the probe was successfully applied for quantitative detection of Cys in fetal bovine serum and real-time imaging in living HeLa cells with low toxicity.