942-57-4Relevant articles and documents
COMPOUNDS
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Page/Page column 84, (2020/01/24)
A compound of formula (I), or a pharmaceutically acceptable salt thereof.
Electrochemical reduction of methyl 2-bromomethylbenzoate at carbon cathodes in dimethylformamide containingwater
Allen, Caroline R.,Brown, Drew K.,Potts, Jessica L.,Ji, Chang
, p. G3069-G3072 (2013/07/05)
Cyclic voltammetry and controlled-potential electrolysis have been employed to examine the electrochemical reduction of methyl 2-bromomethylbenzoate at carbon cathodes in dimethylformamide (DMF) containing tetramethylammonium tetrafluoroborate (TMABF4). A cyclic voltammogram for the reduction of the substrate exhibits one irreversible cathodic wave with a peak potential of -1.45 V vs. SCE, which is due to the two-electron cleavage of the benzylic carbon-bromine bond. The corresponding reductive peak current also increases incrementally with the amount of water in DMF. Bulk electrolyses of methyl 2-bromomethylbenzoate have been carried out at -1.85 V vs. SCE with different concentrations of water in the solvent. The reduction process involves carbanion intermediates to afford various products including phthalide, which is generated via intramolecular cyclization that is affected by the presence of water. Detailed mechanism for the electrochemical reaction is proposed and further studied by isotope incorporation experiment.
Oxidation of Aromatic Compounds. II. Oxidation of Methyl Derivatives of Benzoic Acid and Acetophenone in the System HSO3F-PbO2
Rudenko, A. P.,Korovina, N. S.
, p. 1084 - 1088 (2007/10/03)
Low-temperature oxidation of methyl derivatives of benzoic acid and acetophenone in the system HSO3F-PbO2 proceeds with intermediate formation of radical cations and results in replacement of hydrogen atom in methyl group or benzene ring.The reaction allows preparation of various substituted derivatives of benzyl alcohols and alkylated phthalides.