6134-55-0Relevant articles and documents
Nucleophilic addition to a p-benzyne derived from an enediyne: A new mechanism for halide incorporation into biomolecules
Perrin, Charles L.,Rodgers, Betsy L.,O'Connor, Joseph M.
, p. 4795 - 4799 (2007)
Biosynthesis of haloaromatics ordinarily occurs by electrophilic attack of an activated halogen species on an electron-rich aromatic ring. We now present the discovery of a new reaction whereby a nucleophilic halide anion can be attached even to an aromatic ring without activating substituents. We show that the enediyne cyclodeca-1,5-diyn-3-ene, in the presence of lithium halide and a weak acid, is converted to 1-halotetrahydronaphthalene. The kinetics are consistent with rate-limiting cyclization to a p-benzyne biradical that rapidly adds halide and is then protonated. This reaction has interesting mechanistic features and important implications for incorporation of halide into biomolecules.
13C scrambling of [5-13C]5-cyclodecynone
Wempe, Michael F.,Grunwell, John R.
, p. 6709 - 6713 (2000)
Scrambling of [5-13C]5-cyclodecynone occurs as a result of acidic conditions that preclude its rapid consumption. (C) 2000 Elsevier Science Ltd.
GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE
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Paragraph 001287, (2021/01/22)
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.
New organic compounds and organic light emitting device using the same
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Paragraph 0077, (2016/10/07)
The present invention relates to a polycyclic aromatic hydrocarbon compound in which a substituted or unsubstituted C2-30 cycloalkane, or a substituted or unsubstituted C5-50 polycycloalkane is fused to a substituent of said polycyclic aromatic hydrocarbon as represented by formula (3). Furthermore, the present invention relates to an organic light emitting device comprising a first electrode, at least one organic layer and a second electrode, laminated successively, in which at least one organic layer comprises said polycyclic aromatic hydrocarbon compound.