620-50-8

Basic information

• Product Name: 1,3-bis(3-methylphenyl)urea
• Synonyms: 1,3-Bis(3-methylphenyl)urea; N,N'-bis(3-methylphenyl)urea; urea, N,N'-bis(3-methylphenyl)-
• CAS NO: 620-50-8
• Molecular Formula: C₁₅H₁₆N₂O
• Molecular Weight: 240.3003
• Mol File: 620-50-8.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 296.2°C at 760 mmHg
• Flash Point: 95.6°C
• Density: 1.187g/cm³
• Vapor Pressure: 0.00146mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 1,3-bis(3-methylphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(3-methylphenyl)urea(620-50-8)
• EPA Substance Registry System: 1,3-bis(3-methylphenyl)urea(620-50-8)

Safety Data

• Hazardous Substances Data: 620-50-8(Hazardous Substances Data)

Usage

Type of compound

Urea derivative

Usage

Reagent in organic synthesis, ligand in coordination chemistry

Ability

Forms coordination complexes with various metal ions

Potential applications

Catalysis, medicinal chemistry

Physical appearance

White crystalline solid

Solubility

Sparingly soluble in water, more soluble in organic solvents

Biological activities

Exhibits anti-tumor and anti-viral properties

Research potential

Candidate for further pharmacological research

Scientific interest

Versatile and multifunctional compound, interest in various scientific disciplines

Upstream product

• 621-29-4 3-tolyl isocyanate 
• 108-44-1 1-amino-3-methylbenzene 
• 638-03-9 m-toluidine hydrochloride 
• 57-13-6 urea 
• 626-36-8 ethyl allophanate 
• 3085-53-8 N-formyl-m-toluidine 
• 591-17-3 meta-bromotoluene 
• 13683-89-1 methyl N-(3-hydroxyphenyl)carbamate 
• 587-03-1 3-methylbenzyl alcohol 
• 201230-82-2 carbon monoxide 
• 313549-89-2 (1H-benzo-[d][1,2,3]triazol-1-yl)(m-tolyl)methanone 
• 105-58-8 Diethyl carbonate 
• 621-30-7 3-methylphenyl isothiocyanate 
• 1293990-76-7 N-tert-pentanoyloxy-m-methylbenzamide 

Downstream Products

• 63-99-0 3-methylphenylurea 
• 16596-02-4 N,N'-di(m-tolyl)formamidine 
• 726-28-3 N,N'-bis(m-methylphenyl)carbodiimide 
• 67781-34-4 di(m-tolyl)violuric acid 
• 108-44-1 1-amino-3-methylbenzene 
• 103-71-9 phenyl isocyanate 
• 621-29-4 3-tolyl isocyanate 

Relevant articles and documents

Palladium-Catalyzed Aerobic Oxidative Carbonylation of Amines Enables the Synthesis of Unsymmetrical N,N′-Disubstituted Ureas

A ligand-free palladium-catalyzed aerobic oxidative carbonylation of amines for the synthesis of ureas, particular unsymmetrically N,N′-disubstituted ureas, which cannot be accessed by any other palladium-catalyzed oxidative carbonylation of amines to date, is presented. An array of symmetrical and unsymmetrical ureas were straightforwardly synthesized by using inexpensive, readily available, stable, and safe amines with good to excellent yields under a pressure of 1 atm. This novel method employs oxygen as the sole oxidant and offers an attractive alternative to transition-metal-based oxidant systems.

Amide-assisted rearrangement of hydroxyarylformimidoyl chloride to diarylurea

A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented.

An Improved Synthesis of Urea Derivatives from N -Acylbenzotriazole via Curtius Rearrangement

The good leaving tendency of the benzotriazole moiety has been exploited for the synthesis of symmetric, unsymmetric, N -acyl, and cyclic ureas in good yields from N -acylbenzotriazoles by treating the latter with various amines in the presence of TMSN 3 /Et 3 N in a sealed tube. The salient features of the devised protocol includes the high-yield, mild, metal-free, one-pot reaction conditions, and short reaction time. Furthermore, in many cases, no column chromatography is required for the purification.