3085-53-8

Basic information

• Product Name: 3-METHYLFORMANILIDE
• Synonyms: 3-METHYLFORMANILIDE;N-FORMYL-M-TOLUIDINE;N-(3-Methylphenyl)formamide;N-(m-Tolyl)formamide;3-Methylformamide;N-(3-methylphenyl)methanamide
• CAS NO: 3085-53-8
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.16
• EINECS: 221-398-4
• Mol File: 3085-53-8.mol
• Article Data: 54

Chemical Properties

• Melting Point: <-18 °C
• Boiling Point: 165-167°C 10mm
• Flash Point: 165-167°C/10mm
• Appearance: /
• Density: 1.1031 (rough estimate)
• Vapor Pressure: 0.00156mmHg at 25°C
• Refractive Index: 1.5589 (estimate)
• PKA: 15.00±0.70(Predicted)
• CAS DataBase Reference: 3-METHYLFORMANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLFORMANILIDE(3085-53-8)
• EPA Substance Registry System: 3-METHYLFORMANILIDE(3085-53-8)

Safety Data

• Statements: 21/22
• Safety Statements: 23-36/37/39
• Hazardous Substances Data: 3085-53-8(Hazardous Substances Data)

Usage

General Description

3-Methylformanilide is an organic chemical compound classified under the anilides group. It appears as a yellowish to colorless oily liquid and is known for its sweet, floral, and herbaceous odor. Its chemical formula is C9H11NO and its molecular weight is 149.19 g/mol. It is primarily used in blossoms for spicy, sweet, floral, and tobacco-like odor effects and is also used as a flavoring substance. Since it's moderately toxic, exposure to 3-Methylformanilide should be minimized. Its physical and chemical properties are fairly stable, making it suitable for various uses. Its use should be in compliance with FDA regulations regarding flavoring substances.

InChI:InChI=1/C8H9NO/c1-7-3-2-4-8(5-7)9-6-10/h2-6H,1H3,(H,9,10)

Upstream product

• 33876-93-6 N-(m-methylbenzene)-1-imidazolecarboxamide 
• 96-26-4 dihydroxyacetone 
• 108-44-1 1-amino-3-methylbenzene 
• 121-72-2 N,N-dimethyl-m-toluidine 
• 79-14-1 glycolic Acid 
• 638-03-9 m-toluidine hydrochloride 
• 77287-34-4 formamide 
• 68-12-2 N,N-dimethyl-formamide 
• 667-27-6 Ethyl bromodifluoroacetate 
• 123-91-1 1,4-dioxane 
• 10335-81-6 3-methylphenylhydroxamic acid 
• 1711-06-4 3-Methylbenzoyl chloride 
• 298-12-4 Glyoxilic acid 
• 696-44-6 N-methyl-m-toluidine 

Downstream Products

• 39970-42-8 N-methyl-N-(3-methylphenyl)carboxamide 
• 620-22-4 3-Methylbenzonitrile 
• 64-18-6 formic acid 
• 108-44-1 1-amino-3-methylbenzene 
• 28170-41-4 N,N-dimethyl-N’-(3-methylphenyl)urea 
• 59960-39-3 N-(3-methylphenyl)-α-methyl-benzeneacetamide 
• 638-03-9 m-toluidine hydrochloride 
• 20600-54-8 1-isocyano-3-methylbenzene 
• 39195-18-1 3-methylphenyl isoselenocyanate 
• 921805-83-6 N-(m-tolyl)benzoxazole-2-carboxamide 
• 696-44-6 N-methyl-m-toluidine 
• 16596-02-4 N,N'-di(m-tolyl)formamidine 
• 620-50-8 N,N'-di(m-tolyl)urea 
• 611-05-2 4-nitro-3-methylaniline 

Relevant articles and documents

Copper-Catalyzed Cascade N-Dealkylation/N-Methyl Oxidation of Aromatic Amines by Using TEMPO and Oxygen as Oxidants

A novel tandem N-dealkylation and N-methyl aerobic oxidation of tertiary aromatic amines to N-arylformamides using copper and TEMPO has been developed. This methodology suggested an alternative synthetic route from N-methylarylamines to N-arylformamides.

An Environmentally Benign, Catalyst-Free N?C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides

Herein, we report an operationally simple, cheap, and catalyst-free method for the transamidation of a diverse range of unactivated amides furnishing the desired products in excellent yields. This protocol is environmentally friendly and operates under extremely mild conditions without using any promoter or additives. Significantly, this strategy has been implied in the chemoselective synthesis of a pharmaceutical molecule, paracetamol, on a gram-scale with excellent yield. We anticipate that this universally applicable strategy will be of great interest in drug discovery, biochemistry, and organic synthesis.

Olefin functionalized IPr.HCl monomer as well as preparation method and application thereof

The invention relates to an olefin functionalized IPr.HCl monomer, a preparation method thereof, a method for preparing an N-heterocyclic carbene functionalized organic polymer (PS-IPr-x) by using the olefin functionalized IPr.HCl monomer, and application of the N-heterocyclic carbene functionalized organic polymer as a heterogeneous catalyst for catalyzing reduction N-formylation of carbon dioxide and amine. A heterogeneous catalyst is prepared by using cheap and easily available DVB as a polymerization cross-linking agent through an AIBN-initiated olefin polymerization method, and has the advantages of low preparation cost and simple preparation method. Meanwhile, the catalytic activity of the catalyst is obviously higher than that of reported catalysts, and the catalyst has a wide practical application prospect.