6274-54-0

Basic information

• Product Name: 4-METHANESULFONYL-BENZOIC ACID ETHYL ESTER
• Synonyms: 4-METHANESULFONYL-BENZOIC ACID ETHYL ESTER;Ethyl 4-(methylsulfonyl)benzoate
• CAS NO: 6274-54-0
• Molecular Formula: C₁₀H₁₂O₄S
• Molecular Weight: 228.27
• Mol File: 6274-54-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 387.2°C at 760 mmHg
• Flash Point: 188°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 3.35E-06mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: 4-METHANESULFONYL-BENZOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHANESULFONYL-BENZOIC ACID ETHYL ESTER(6274-54-0)
• EPA Substance Registry System: 4-METHANESULFONYL-BENZOIC ACID ETHYL ESTER(6274-54-0)

Safety Data

• Hazardous Substances Data: 6274-54-0(Hazardous Substances Data)

Usage

Description

4-Methanesulfonyl-benzoic acid ethyl ester, with the molecular formula C10H12O4S, is a white to off-white solid chemical compound. It serves as an intermediate in the production of pharmaceuticals and agrochemicals and is commonly used as a reagent in organic synthesis for the creation of various active pharmaceutical ingredients. Additionally, it is utilized in the production of agricultural chemicals and dyes. 4-METHANESULFONYL-BENZOIC ACID ETHYL ESTER is considered stable and non-hazardous, with no specific regulations on its use.

Uses

Used in Pharmaceutical Industry:
4-Methanesulfonyl-benzoic acid ethyl ester is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the efficacy of existing medications.
Used in Agrochemical Production:
In the agrochemical industry, 4-Methanesulfonyl-benzoic acid ethyl ester is used as a precursor in the production of agricultural chemicals, helping to create compounds that protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
4-Methanesulfonyl-benzoic acid ethyl ester is used as a reagent in organic synthesis, enabling the creation of a wide range of chemical compounds for various applications.
Used in Dye Production:
4-METHANESULFONYL-BENZOIC ACID ETHYL ESTER is also utilized in the production of dyes, contributing to the development of new colorants for various industries, including textiles, plastics, and printing.

InChI:InChI=1/C10H12O4S/c1-3-14-10(11)8-4-6-9(7-5-8)15(2,12)13/h4-7H,3H2,1-2H3

Upstream product

• 15226-74-1 dicobalt octacarbonyl 
• 64-17-5 ethanol 
• 57728-86-6 4-(methylsulfonyl)phenyl trifluoromethanesulfonate 
• 14763-60-1 4-methanesulfonyl-phenol 
• 4052-30-6 4-methylsulfonylbenzoic acid 
• 40913-92-6 4-methylsulfonylbenzoyl chloride 

Downstream Products

• 69564-67-6 4-(ethoxycarbonyl)-benzenesulfinic acid 
• 40517-43-9 1-(chloromethyl)-4-(methylsulfonyl)benzene 
• 130935-96-5 (E)-1,2-bis(4-(methylsulfonyl)phenyl)ethene 
• 53606-06-7 4-(methylsulfonyl)benzyl bromide 
• 93629-02-8 p-methylsulfonylbenzyl mercaptan 
• 578727-33-0 1-(4-fluorophenylamino)-N-methyl-N-phenylsulfonyl-4-methylsulfonylbenzohydrazone 
• 578727-27-2 C₁₆H₁₈N₂O₅S₂ 
• 578727-30-7 C₁₆H₁₇ClN₂O₄S₂ 
• 578727-25-0 N-(4-methylsulfonylbenzoyl)-N'-methyl-N'-phenylsulfonylhydrazide 
• 578727-24-9 N-(4-methylsulfonylbenzoyl)-N'-phenylsulfonylhydrazide 
• 578727-29-4 N-methyl-N-phenylsulfonyl-4-(methylsulfonyl)benzohydrazonoyl chloride 
• 578727-34-1 4-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)-1,2,4-triazole 
• 861805-00-7 4-[4-(4-methanesulfonyl-phenyl)-4-oxo-3-pyridin-4-yl-butyryl]-piperidine-1-carboxylic acid benzyl ester 
• 861804-80-0 4-[5-(4-methanesulfonyl-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Method for synthesizing aryl alkyl sulfone compound by promoting oxidation of aryl alkyl thioether compound through visible light

The invention discloses a method for synthesizing an aryl alkyl sulfone compound by promoting oxidation of an aryl alkyl thioether compound through visible light. The method comprises the following steps of: performing one-pot reaction on an aryl alkyl thioether compound and sodium trifluoromethanesulfinate in a diethylene glycol dibutyl ether solution system under the conditions of oxygen-containing atmosphere and 385-390 nm purple light irradiation to generate the aryl alkyl sulfone compound. The method has the advantages of mild conditions, simple operation, environmental protection, easilyavailable raw materials, excellent compatibility of substrate functional groups, high reaction yield and the like.

Synthesis of novel benzohydrazides bearing 4-[3-methyl-4-(methylsulfonyl)pyridin-2-yl] moiety as potential antibacterial agents

This work reports the synthesis and antibacterial activity of novel hydrazone derivatives 8a-k bearing 4-[3-methyl-4-(methylsulfonyl)pyridin- 2-yl] moiety. Spectroscopic techniques like 1H NMR, mass and IR tools was utilized for the characterization of these hydrazone derivatives. The synthesized hydrazone derivatives were tested against a set of bacterial strains, namely, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pyogenes by paper disc diffusion method. Compounds 8b, 8d, 8e, 8f, 8h, 8i showed good antibacterial activity against the test organisms.

Synthesis and antibacterial activity of some new quinaxaline-benzohydrazides

Quinoxalines have been found to exhibit various biological activities such as antibacterial, antifungal, anti-tubercular, anxiolytic, anticancer, antioxidant, anti-inflammatory, anti-HIV, antihelmintic and anticonvulsant. The present study aims towards synthesis, characterization and determination of antimicrobial susceptibility testing of various novel quinoxaline derivatives. The quinoxaline-benzohydrazides 6a-m have been obtained by the condensation of quinoxaline-2-carboxaldehyde 4 with various benzohydrazides 5a-m in ethanol at reflux temperature. All the newly synthesized quinoxaline-benzohydrazide derivatives have been characterized by 1H NMR, IR and mass spectroscopic analysis. The synthesized quinoxaline-benzohydrazides 6a-m have been screened for antibacterial activity. Most of the compounds show significant antibacterial activity.