62921-74-8 Usage
Description
2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate, also known as m-PEG4-Tos, is a PEG linker containing a tosyl group. The tosyl group serves as an excellent leaving group for nucleophilic substitution reactions, while the hydrophilic PEG spacer enhances solubility in aqueous media. This unique structure makes m-PEG4-Tos a versatile compound with potential applications in various fields.
Uses
Used in Organic Synthesis:
m-PEG4-Tos is used as a protecting group in organic synthesis for alcohols, particularly in the synthesis of complex organic molecules. The tosyl group's reactivity as a leaving group allows for selective protection and deprotection of alcohols during multi-step reactions, facilitating the synthesis of target molecules.
Used in Bioconjugation:
In the field of bioconjugation, m-PEG4-Tos is employed as a coupling agent to attach biomolecules, such as proteins or nucleic acids, to other molecules or surfaces. The tosyl group's reactivity enables the formation of stable covalent bonds with nucleophilic functional groups present in biomolecules, allowing for the creation of bioconjugates with controlled structure and function.
Used in Drug Delivery Systems:
m-PEG4-Tos is utilized as a component in the design of drug delivery systems, particularly for the development of targeted drug carriers. The hydrophilic PEG spacer improves the solubility and stability of drug carriers in aqueous environments, while the tosyl group can be used for selective conjugation of therapeutic agents, enabling the development of targeted drug delivery systems with enhanced efficacy and reduced side effects.
Used in Material Science:
In material science, m-PEG4-Tos is used as a building block for the synthesis of novel polymers and materials with tailored properties. The combination of the hydrophilic PEG spacer and the reactive tosyl group allows for the creation of materials with specific interactions, such as self-assembly, stimuli-responsive behavior, or controlled release of encapsulated molecules.
Used in Analytical Chemistry:
m-PEG4-Tos is employed as a derivatization agent in analytical chemistry for the enhancement of detection and analysis of various analytes. The tosyl group's reactivity enables the formation of stable derivatives with improved chromatographic or spectroscopic properties, facilitating the detection and quantification of target analytes in complex samples.
Check Digit Verification of cas no
The CAS Registry Mumber 62921-74-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,9,2 and 1 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 62921-74:
(7*6)+(6*2)+(5*9)+(4*2)+(3*1)+(2*7)+(1*4)=128
128 % 10 = 8
So 62921-74-8 is a valid CAS Registry Number.
62921-74-8Relevant articles and documents
TPE based aggregation induced emission fluorescent sensors for viscosity of liquid and mechanical properties of hydrogel
Wang, Na,Yao, Hang,Tao, Qi,Sun, Jing,Ma, Hao,Wang, Yang,Zhou, ChengCheng,Fan, Hongying,Shao, Hongxia,Qin, Aijian,Su, Dawei,Wang, Chenyin,Chong, Hui
supporting information, p. 252 - 256 (2021/08/13)
Two amphiphilic TPE E/Z isomers with aggregation induced emission (AIE) property have been synthesized and characterized. The logarithmic fluorescent intensity of the two molecules was in positive relationship with logarithmic viscosity of liquid. To note
Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors
Kobayakawa, Takuya,Tsuji, Kohei,Konno, Kiju,Himeno, Ai,Masuda, Ami,Yang, Tingting,Takahashi, Kohei,Ishida, Yusuke,Ohashi, Nami,Kuwata, Takeo,Matsumoto, Kaho,Yoshimura, Kazuhisa,Sakawaki, Hiromi,Miura, Tomoyuki,Harada, Shigeyoshi,Matsushita, Shuzo,Tamamura, Hirokazu
supporting information, p. 1481 - 1496 (2021/02/27)
CD4 mimics are small molecules that inhibit the interaction of gp120 with CD4. We have developed several CD4 mimics. Herein, hybrid molecules consisting of CD4 mimics with a long alkyl chain or a PEG unit attached through a self-cleavable linker were synthesized. In anti-HIV activity, modification with a PEG unit appeared to be more suitable than modification with a long alkyl chain. Thus, hybrid molecules of CD4 mimics, with PEG units attached through an uncleavable linker, were developed and showed high anti-HIV activity and low cytotoxicity. In investigation of pharmacokinetics in a rhesus macaque, a hybrid compound had a more effective PK profile than that of the parent compound, and intramuscular injection was a more useful administration route to maintain the high blood concentration of the CD4 mimic than intravenous injection. The presented hybrid molecules of CD4 mimics with a PEG unit would be practically useful when combined with a neutralizing antibody.
Construction of Janus dendrimers through a self-assembly approach involving chiral discrimination at a focal point
Zhou, John,Cole, Ashley M.,Menuey, Elizabeth M.,Kilway, Kathleen V.,Moteki, Shin A.
supporting information, p. 6404 - 6407 (2021/07/02)
A strategy to build Janus dendrimersviathe chirality-directed self-assembly of heteroleptic Zn(ii) BOX complexes is reported. The method allows quantitative synthesis of Janus dendrimersin situwithout the need for purifications. Each dendritic domain of t
