631910-23-1

Basic information

• Product Name: Carbamic acid, (5-methyl-3-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, (5-methyl-3-pyridinyl)-, 1,1-dimethylethyl ester (9CI);tert-Butyl (5-methylpyridin-3-yl)carbamate;tert-butyl N-(5-methyl-3-pyridyl)carbamate;Tert-Butyl (5-Methylpyridin-3-Yl)Carbamate(WXC03756)
• CAS NO: 631910-23-1
• Molecular Formula: C₁₁H₁₆N₂O₂
• Molecular Weight: 208.25694
• Product Categories: N-BOC
• Mol File: 631910-23-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 272.3±28.0 °C(Predicted)
• Appearance: /
• Density: 1.108±0.06 g/cm3(Predicted)
• PKA: 12.93±0.70(Predicted)
• CAS DataBase Reference: Carbamic acid, (5-methyl-3-pyridinyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (5-methyl-3-pyridinyl)-, 1,1-dimethylethyl ester (9CI)(631910-23-1)
• EPA Substance Registry System: Carbamic acid, (5-methyl-3-pyridinyl)-, 1,1-dimethylethyl ester (9CI)(631910-23-1)

Safety Data

• Hazardous Substances Data: 631910-23-1(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 3430-19-1 5-methylpyridin-3-amine 
• 3222-49-9 5-methylnicotinic acid 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 1270019-95-8 cis-(+/-)-tert-butyl 5-methylpiperidin-3-ylcarbamate 
• 1405128-95-1 tert-butyl ((3S,5R)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-5-methylpiperidin-3-yl)carbamate 
• 1270019-95-8 cis-(+/-)-tert-butyl 5-methylpiperidin-3-ylcarbamate 
• 1187055-56-6 C₁₁H₂₂N₂O₂ 
• 1405126-53-5 N-(4-((3S,5S)-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine 
• 1405126-60-4 N-(4-((3S,5R)-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine 
• 1203651-07-3 tert-butyl ((3S,5R)-5-methylpiperidin-3-yl)carbamate 
• 1270019-95-8 (3S,5S)-(5-Methyl-piperidin-3-yl)-carbamic acid tert-butyl ester 
• 1270019-92-5 ((3R,5S)-5-methylpiperidin-3-yl)carbamic acid tert-butyl ester 

Relevant articles and documents

POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS

The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroary; and X is C(R4)2, O, NR4, S, S(R4), or S(R4)2.

Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors

High levels of Pim expression have been implicated in several hematopoietic and solid tumor cancers, suggesting that inhibition of Pim signaling could provide patients with therapeutic benefit. Herein, we describe our progress towards this goal using a screening hit (rac-1) as a starting point. Modification of the indazole ring resulted in the discovery of a series of imidazopyridazine-based Pim inhibitors exemplified by compound 22m, which was found to be a subnanomolar inhibitor of the Pim-1 and Pim-2 isoforms (IC50values of 0.024?nM and 0.095?nM, respectively) and to potently inhibit the phosphorylation of BAD in a cell line that expresses high levels of all Pim isoforms, KMS-12-BM (IC50?=?28?nM). Profiling of Pim-1 and Pim-2 expression levels in a panel of multiple myeloma cell lines and correlation of these data with the potency of compound 22m in a proliferation assay suggests that Pim-2 inhibition would be advantageous for this indication.

PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYR-ROLO[2,3-D]PYRIDINYL ACRYLAMIDES

The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.