6338-55-2 Usage
Description
2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL, also known as (PEO)3-monoamine, is a poly(ethylene oxide) (PEO) blocking agent that is utilized to prevent nonspecific adsorption of analytes in various applications, particularly in covalent protein coupling techniques such as ELISA. 2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL is characterized by its ability to reduce the adsorption of IgG when coated on carboxylic-terminated surfaces, thereby enhancing the specificity and accuracy of the assays.
Uses
Used in Diagnostic Applications:
2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL is used as a blocking agent for preventing nonspecific adsorption of analytes in diagnostic assays such as ELISA. The application reason is to enhance the specificity and accuracy of the assays by reducing the adsorption of IgG on carboxylic-terminated surfaces.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL is used as a stabilizing agent for protein formulations. The application reason is to improve the stability and shelf life of protein-based drugs by minimizing their interaction with surfaces and reducing the risk of aggregation.
Used in Research and Development:
2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL is used as a research tool for studying protein-surface interactions and developing novel protein coupling techniques. The application reason is to provide a means to investigate the underlying mechanisms of nonspecific adsorption and to design more effective strategies for minimizing it in various experimental setups.
Used in Surface Modification:
In the field of surface modification, 2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL is used as a coating agent to create surfaces with reduced protein adsorption properties. The application reason is to develop surfaces that are less prone to fouling and biocompatibility issues, which can be beneficial in various applications such as medical devices, sensors, and lab-on-a-chip systems.
Check Digit Verification of cas no
The CAS Registry Mumber 6338-55-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,3 and 8 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6338-55:
(6*6)+(5*3)+(4*3)+(3*8)+(2*5)+(1*5)=102
102 % 10 = 2
So 6338-55-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H15NO3/c7-1-3-9-5-6-10-4-2-8/h8H,1-7H2
6338-55-2Relevant articles and documents
Cofactor-free detection of phosphatidylserine with cyclic peptides mimicking lactadherin
Zheng, Hong,Wang, Fang,Wang, Qin,Gao, Jianmin
, p. 15280 - 15283 (2011)
Cyclic peptides (cLacs) are designed to mimic the natural phosphatidylserine (PS) binding protein lactadherin. Unlike annexin V or its small molecule mimics, the cLac peptides selectively target PS-presenting membranes with no need for metal cofactors. We further show that a fluorophore-labeled cLac effectively stains early apoptotic cells. The small size and facile conjugation with a variety of imaging tracers make the cLac design promising for imaging cell death in vitro as well as in living organisms.
MERTK DEGRADERS AND USES THEREOF
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Paragraph 00974, (2020/01/31)
The present invention provides compounds, compositions thereof, and methods of using the same.
NIRF turn-on nanoparticles based on the tumor microenvironment for monitoring intracellular protein delivery
Xu, Huaibao,Wang, Yi,Pei, Zhichao,Ji, Wei,Pei, Yuxin
, p. 14930 - 14933 (2019/12/24)
A dual responsive NIRF turn-on protein delivery system incorporating an NIRF turn-on probe and protein into one single nanoparticle has been constructed. It can be taken up efficiently by A549 cells, where protein release and NIRF recovery happen simultaneously in response to low pH and excessive H2O2. This work provides a novel system for monitoring intracellular protein delivery.
