63979-60-2

Basic information

• Product Name: N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]dodecanamide
• Synonyms: N-[1,1-Di(hydroxymethyl)-2-hydroxyethyl]dodecanamide;N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]dodecanamide;USAF ND-75
• CAS NO: 63979-60-2
• Molecular Formula: C16H33 N O4
• Molecular Weight: 303.4375
• Mol File: 63979-60-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 537.3°Cat760mmHg
• Flash Point: 278.8°C
• Appearance: /
• Density: 1.042g/cm³
• Vapor Pressure: 8.69E-14mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]dodecanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]dodecanamide(63979-60-2)
• EPA Substance Registry System: N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]dodecanamide(63979-60-2)

Safety Data

• Hazardous Substances Data: 63979-60-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H33NO4/c1-2-3-4-5-6-7-8-9-10-11-15(21)17-16(12-18,13-19)14-20/h18-20H,2-14H2,1H3,(H,17,21)

Upstream product

• 99224-14-3 β-Keto tridecanol 
• 77-86-1 2-amino-2-hydroxymethyl-1,3-propanediol 
• 143-07-7 lauric acid 
• 112-16-3 n-dodecanoyl chloride 
• 1185-53-1 tris hydrochloride 
• 1146965-61-8 N-[tris(tert-butyldimethylsilyloxymethyl)methyl]dodecamide 

Relevant articles and documents

One-step coupling of tris(hydroxymethyl)aminomethane to aliphatic and aromatic carboxylic acids

A convenient and general method was established to append tri-, hexa-, and nonadentate ligands about an aromatic or aliphatic core. This approach allows a variety of commercially available carboxylic acids to be transformed to their N-tris(hydroxymethyl)m

Binding of a Fatty Acid-Functionalized Anderson-Type Polyoxometalate to Human Serum Albumin

The Anderson-type hexamolybdoaluminate functionalized with lauric acid (LA), (TBA)3[Al(OH)3Mo6O18{(OCH2)3CNHCOC11H23}]·9H2O (TBA-AlMo6-LA, where TBA = tetrabutylammonium), was prepared via two synthetic routes and characterized by thermogravimetric and elemental analyses, mass spectrometry, IR and 1H NMR spectroscopy, and powder and single-crystal X-ray diffraction. The interaction of TBA-AlMo6-LA with human serum albumin (HSA) was investigated via fluorescence and circular dichroism spectroscopy. The results revealed that TBA-AlMo6-LA binds strongly to HSA (63% quenching at an HSA/TBA-AlMo6-LA ratio of 1:1), exhibiting static quenching. In contrast to TBA-AlMo6-LA, the nonfunctionalized polyoxometalate, Na3(H2O)6[Al(OH)6Mo6O18]·2H2O (AlMo6), showed weak binding toward HSA (22% quenching at a HSA/AlMo6 ratio of 1:25). HSA binding was confirmed by X-ray structure analysis of the HSA-Myr-AlMo6-LA complex (Myr = myristate). These results provide a promising lead for the design of novel polyoxometalate-based hybrids that are able to exploit HSA as a delivery vehicle to improve their pharmacokinetics and bioactivity.

Safe and efficient in vitro and in vivo gene delivery: Tripodal cationic lipids with programmed biodegradability

The therapeutic use of nucleic acids has long been heralded as a panacea of medicinal opportunity, a vision enhanced by the introduction of RNA interference technology. The Achilles heel of such an approach is the in vivo delivery of the desired nucleic acid into cells, a practice that lacks selectivity, safety and/or efficiency. Herein we report the safe and efficacious in vitro and in vivo delivery of nucleic acids using tripodal biodegradable cationic lipids. Toxicity reduction and transfection potency of these novel amphiphiles were addressed by designing the compounds to undergo complete intracellular degradation thereby enhancing cargo release while minimising toxicity and potential tissue accumulation. Compounds demonstrated high-efficiency in transfecting DNA into cells both in vitro and in vivo with no signs of toxicity, thus potentially offering a safer alternative to viral transfection for gene therapy application. The Royal Society of Chemistry.