65023-19-0 Usage
Description
(4aS,6aR,6bS,10R,12aS,14aR,14bR)-Methyl 10-hydroxy-2,2,6a,6b,9,9,12a-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4a-carboxylate is a complex organic molecule characterized by its long and specific chemical structure. It features a methyl group, a hydroxy group, and a carboxylate group, along with a series of fused cycloalkane rings and multiple methyl substituents. (4aS,6aR,6bS,10R,12aS,14aR,14bR)-Methyl 10-hydroxy-2,2,6a,6b,9,9,12a-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4a-carboxylate is highly hydrophobic and likely has low water solubility due to its complex and bulky structure, which may result in unique chemical and physical properties. Its synthesis and potential applications are of interest to synthetic chemists and researchers in the field of organic chemistry.
Uses
Used in Pharmaceutical Industry:
(4aS,6aR,6bS,10R,12aS,14aR,14bR)-Methyl 10-hydroxy-2,2,6a,6b,9,9,12a-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4a-carboxylate is used as a potential pharmaceutical compound for [application reason]. Its unique structure and properties may offer novel therapeutic opportunities, such as targeting specific biological pathways or interacting with certain receptors.
Used in Chemical Research:
In the field of chemical research, (4aS,6aR,6bS,10R,12aS,14aR,14bR)-Methyl 10-hydroxy-2,2,6a,6b,9,9,12a-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4a-carboxylate is used as a subject of study for [application reason]. Its synthesis and analysis can provide insights into the behavior of complex organic molecules and contribute to the development of new synthetic methods or understanding of molecular interactions.
Used in Material Science:
(4aS,6aR,6bS,10R,12aS,14aR,14bR)-Methyl 10-hydroxy-2,2,6a,6b,9,9,12a-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4a-carboxylate is used as a component in the development of new materials for [application reason]. Its hydrophobic nature and structural characteristics may be exploited to create materials with specific properties, such as improved stability or novel interactions with other molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 65023-19-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,0,2 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 65023-19:
(7*6)+(6*5)+(5*0)+(4*2)+(3*3)+(2*1)+(1*9)=100
100 % 10 = 0
So 65023-19-0 is a valid CAS Registry Number.
65023-19-0Relevant articles and documents
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McKean,Manson,Spring
, p. 432,434 (1952)
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Efficient and scalable synthesis of bardoxolone methyl (CDDO-methyl ester)
Fu, Liangfeng,Gribble, Gordon W.
, p. 1622 - 1625 (2013/07/05)
Bardoxolone methyl (2-cyano-3,12-dioxooleane-1,9(11)-dien-28-oic acid methyl ester; CDDO-Me) (1), a synthetic oleanane triterpenoid with highly potent anti-inflammatory activity (levels below 1 nM), has completed a successful phase I clinical trial for the treatment of cancer and a successful phase II trial for the treatment of chronic kidney disease in type 2 diabetes patients. Our synthesis of bardoxolone methyl (1) proceeds in ~50% overall yield in five steps from oleanolic acid (2), requires only one to two chromatographic purifications, and can provide gram quantities of 1.
Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages
Honda, Tadashi,Rounds, BarbieAnn V.,Gribble, Gordon W.,Suh, Nanjoo,Wang, Yongping,Sporn, Michael B.
, p. 2711 - 2714 (2007/10/03)
New derivatives with electron-withdrawing substituents at the C-2 position of 3-oxoolean-1-en-28-oic acid were synthesized. Among them, 2- cyano-3,12-dioxoleam-1,9-dien-28-oic acid (CDDO) was 400 times more potent than previous compounds we have made as an inhibitor of production of nitric oxide induced by interferon γ in mouse macrophages (IC50, 0.4 nM). The potency of CDDO was similar to that of dexamethasone, although CDDO does not act through the glucocorticoid receptor.