68430-29-5Relevant articles and documents
Stereospecific hydrolysis of 2-oxazolidinone esters and separation of products with an immobilized lipase column
Hamaguchi,Asada,Hasegawa,Watanabe
, p. 1661 - 1667 (1985)
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Method of preparing a heterocyclic intermediate for the production of optically active aryloxysubstituted vicinal aminoalcohols
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, (2008/06/13)
The invention relates to a method of preparing a heterocyclic intermediate of the general formula wherein, X is a carbonyl group, a thiocarbonyl group, a (C1-C10)(ar)alkylidene group or a dihydrocarbylsilyl group, R is a straight or branched (C1-C10)alkyl group, optionally substituted with halogen, hydroxy, (C1-C4)alkoxy or protected hydroxy, or a phenyl(C1-C3)alkyl or heteroaryl(C1-C3)alkyl group, which groups are optionally substituted with 1-3 substituents, selected from the group consisting of hydroxy, (C5-C12)cycloalkyl, amino, nitro, halogen, cyano, alkoxy, alkylcarbonyloxy, alkylcarbonylamino, alkylsulphonylamino, alkylsulphonyl, alkylcarbonyl, and alkyl, wherein the alkyl groups have 1-5 carbon atoms,and which intermediate has either the R or the S configuration, by subjecting an optically active cyanohydrin of the general formula to a reduction-transimination-reduction sequence, using R - NH2 as the primary amine,followed by a cyclization reaction and, finally, by an ozonolysis-reduction sequence.
CHIRAL AMINO ALCOHOLS FROM BAKER'S YEAST REDUCTION OF α-KETO-ACID DERIVATIVES
Pedrocchi-Fantoni, Giuseppe,Redaelli, Silvio,Servi, Stefano,Hoegberg, Hans-Erik
, p. 499 - 502 (2007/10/02)
Baker's yeast reduction of α-keto-acid derivatives gives α-hydroxy esters and amides of varying enantiomeric excesses.In the case of the keto amide, an amino alcohol of high optical purity is formed.The product obtained is transformed in key intermediates in the synthesis of (S)-propranolol.