68430-37-5

Basic information

• Product Name: 2-Oxazolidinone,5-(hydroxymethyl)-3-(1-methylethyl)-,(5R)-(9CI)
• Synonyms: 2-Oxazolidinone,5-(hydroxymethyl)-3-(1-methylethyl)-,(5R)-(9CI)
• CAS NO: 68430-37-5
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.18
• Product Categories: ISOPROPYL
• Mol File: 68430-37-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 346.1±15.0 °C(Predicted)
• Appearance: /
• Density: 1.153±0.06 g/cm3(Predicted)
• PKA: 14.05±0.10(Predicted)
• CAS DataBase Reference: 2-Oxazolidinone,5-(hydroxymethyl)-3-(1-methylethyl)-,(5R)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone,5-(hydroxymethyl)-3-(1-methylethyl)-,(5R)-(9CI)(68430-37-5)
• EPA Substance Registry System: 2-Oxazolidinone,5-(hydroxymethyl)-3-(1-methylethyl)-,(5R)-(9CI)(68430-37-5)

Safety Data

• Hazardous Substances Data: 68430-37-5(Hazardous Substances Data)

Upstream product

• 83277-30-9 5-hydroxymethyl-3-isopropyloxazolidin-2-one 
• 154475-74-8 (+)-(R,E)-N-(benzyloxycarbonyl)-1-(isopropylamino)pent-3-en-2-ol 
• 154475-72-6 (-)-(R,E)-1-(isopropylamino)pent-3-en-2-ol 
• 154475-75-9 (-)-(S)-3-isopropyl-5-(prop-1-enyl)oxazolidin-2-one 
• 116907-39-2 Butyric acid (R)-3-isopropyl-2-oxo-oxazolidin-5-ylmethyl ester 
• 116809-23-5 Propionic acid (R)-3-isopropyl-2-oxo-oxazolidin-5-ylmethyl ester 
• 116908-87-3 Acetic acid (R)-3-isopropyl-2-oxo-oxazolidin-5-ylmethyl ester 

Downstream Products

• 68430-29-5 (S)-5-hydroxymethyl-3-(methylethyl)oxazolidinone 
• 97988-45-9 (R)-3-isopropylamino-1,2-propanediol 

Relevant articles and documents

Synthesis of (R)- and (S)-5-(hydroxymethyl)-3-isopropyloxazolidin-2-one, intermediates in the preparation of optically active β-blockers

The (R)- and (S)-5-(hydroxymethyl)-3-isopropyloxazolidin-2-ones, ((R)- and (S)-2, resp.), pivotal intermediates in the preparation of optically active β-blockers, were synthesized using (R,E)-2-hydroxypent-3-enenitrile (1) as the chiral starting material.

Anhydrides as Acylating Agents in Lipase-Catalyzed Stereoselective Esterification of Racemic Alcohols

A new enzymatic method for the resolution of optically active alcohols from racemates is reported.It involves lipase-catalyzed esterification in organic solvents, with acetic, propionic, or butyric anhydrides as acylating agents.Lipase Amano P, from Pseudomonas fluorescens, adsorbed on Celite 577, was employed as stereoselective catalyst.Under these reaction conditions, the enzyme is not chemically modified by the anhydrides.A number of primary and secondary alcohols have been obtained in high optical purity by this procedure.

Stereospecific hydrolysis of 2-oxazolidinone esters and separation of products with an immobilized lipase column

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