83277-30-9

Basic information

• Product Name: 5-(hydroxymethyl)-3-(1-methylethyl)oxazolidin-2-one
• Synonyms: 5-(hydroxymethyl)-3-(1-methylethyl)oxazolidin-2-one;2-Oxazolidinone,5-(hydroxymethyl)-3-(1-methylethyl)-(9CI);5-(Hydroxymethyl)-3-(1-methylethyl)-2-oxazolidinone;Einecs 280-362-6
• CAS NO: 83277-30-9
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.18302
• EINECS: 280-362-6
• Product Categories: ISOPROPYL
• Mol File: 83277-30-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 346.1°Cat760mmHg
• Flash Point: 163.1°C
• Appearance: /
• Density: 1.153g/cm³
• Vapor Pressure: 3.67E-06mmHg at 25°C
• Refractive Index: 1.48
• CAS DataBase Reference: 5-(hydroxymethyl)-3-(1-methylethyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(hydroxymethyl)-3-(1-methylethyl)oxazolidin-2-one(83277-30-9)
• EPA Substance Registry System: 5-(hydroxymethyl)-3-(1-methylethyl)oxazolidin-2-one(83277-30-9)

Safety Data

• Hazardous Substances Data: 83277-30-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H13NO3/c1-5(2)8-3-6(4-9)11-7(8)10/h5-6,9H,3-4H2,1-2H3

Upstream product

• 99726-37-1 N-(2-propenyl)-1-methylethanamine hydrobromide 
• 6452-57-9 1,2-dihydroxy-3-isopropylaminopropane 
• 616-38-6 carbonic acid dimethyl ester 
• 124-38-9 carbon dioxide 
• 50666-68-7 3-isopropylamino-2-hydroxy-1-chloropropane 
• 99726-38-2 5-(iodomethyl)-3-isopropyloxazolidin-2-one 
• 78723-67-8 5-bromomethyl-3-(1-methylethyl)oxazolidin-2-one 
• 95360-67-1 (R,S)-5-acetoxymethyl-3-isopropyl-oxazolidin-2-one 
• 584-08-7 potassium carbonate 
• 75-31-0 isopropylamine 
• 3132-64-7 1,2-Epoxy-3-bromopropane 

Downstream Products

• 116908-87-3 Acetic acid (R)-3-isopropyl-2-oxo-oxazolidin-5-ylmethyl ester 
• 68430-29-5 (S)-5-hydroxymethyl-3-(methylethyl)oxazolidinone 
• 116809-23-5 Propionic acid (R)-3-isopropyl-2-oxo-oxazolidin-5-ylmethyl ester 
• 525-66-6 propranolol 
• 68430-37-5 (+)-(R)-5-(hydroxymethyl)-3-isopropyloxazolidin-2-one 
• 1182705-22-1 C₁₃H₁₇NO₅S 
• 1612878-78-0 5-(4-benzhydryl-piperazin-1-ylmethyl)-3-isopropyl-oxazolidin-2-one 
• 194732-25-7 N-{4-amino-2-[3-(1-methylethyl)-2-oxo-oxazolidin-5-ylmethoxy]pyridin-3-yl}-2,4-dimethoxybenzamide 
• 194732-44-0 N-{4-amino-6-[3-(1-methylethyl)-2-oxo-oxazolidin-5-ylmethoxy]pyridin-3-yl}-2,4-dimethoxybenzamide 
• 194732-27-9 5-[2-(2,4-Dimethoxy-phenyl)-1H-imidazo[4,5-c]pyridin-4-yloxymethyl]-3-isopropyl-oxazolidin-2-one 
• 194732-46-2 5-[2-(2,4-Dimethoxy-phenyl)-1H-imidazo[4,5-c]pyridin-6-yloxymethyl]-3-isopropyl-oxazolidin-2-one 
• 116907-39-2 Butyric acid (R)-3-isopropyl-2-oxo-oxazolidin-5-ylmethyl ester 

Relevant articles and documents

Switchable synthesis of cyclic carbamates by carbon dioxide fixation at atmospheric pressure

The base-promoted switchable synthesis of five- and six-membered cyclic carbamates using atmospheric pressure carbon dioxide as the C1 source was developed. The chemoselectivity of products was simply controlled by changing bases and solvents. The reaction proceeds effectively under mild conditions, affording valuable cyclic carbamates. Experimental results and DFT studies revealed the reaction mechanism.

MANUFACTURE OF BISOPROLOL AND INTERMEDIATES THEREFOR

A process for preparing bisoprolol comprises reacting oxazolidinone sulphonate with 4-hydroxybenzylaldehyde to form oxazolidinone benzaldehyde, forming oxazolidone benzylalcohol from oxazolidone benzaldehyde, and subsequently reacting oxazolidinone benzylalcohol with isopropyl oxitol to form bisoprolol base. Oxazolidone sulphonate and oxazolidone benzaldehyde are novel intermediates.

Oxazolidin-2-ones from allylic amines by means of iodine and carbonate anion on polymeric support. A convenient synthesis of (±)-propranolol

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