6950-53-4

Basic information

• Product Name: 2-methylsulfanylethanamine
• Synonyms: 2-methylsulfanylethanamine;EthanaMine, 2-(Methylthio)-, hydrochloride;2-(Methylthio)ethanamine HCl
• CAS NO: 6950-53-4
• Molecular Formula: C₃H₉NS*ClH
• Molecular Weight: 0
• EINECS: 201-203-9
• Mol File: 6950-53-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 120 °C
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-methylsulfanylethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylsulfanylethanamine(6950-53-4)
• EPA Substance Registry System: 2-methylsulfanylethanamine(6950-53-4)

Safety Data

• Hazardous Substances Data: 6950-53-4(Hazardous Substances Data)

Usage

General Description

2-methylsulfanylethanamine, also known as dimethylamine, is a chemical compound that belongs to the class of organic compounds known as thioethanamines. It is a colorless liquid with a strong, fishy odor. Chemically, it contains sulfur, hydrogen, nitrogen, and carbon atoms. It plays an essential role in various biological systems and is used in different industrial processes such as the manufacturing of pesticides and the rubber process. Additionally, it is used in the molecular biology field, research labs, and the paper and textile industries.

Upstream product

• 174360-08-8 tert-butyl (2-(methylthio)ethyl)carbamate 
• 18542-42-2 (2-aminoethyl)methylsulfide 

Downstream Products

• 1442655-93-7 C₂₆H₃₈N₄S₂ 
• 174360-08-8 tert-butyl (2-(methylthio)ethyl)carbamate 
• 1275595-87-3 6-(5-((2-(methylthio)ethylamino)methyl)furan-2-yl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-4-quinazolinamine 
• 1361456-15-6 C₆H₅-C{NH(CH₂)2SMe}=NC₆H₅ 

Relevant articles and documents

Novel anthranilic diamide insecticides: Design, synthesis, and insecticidal evaluation

Three series of new anthranilic diamide derivatives containing sulfide, N-cyanomethylsulfilimine, and N-cyanomethylsulfoximine groups were designed and synthesized by coupling the active substructures of anthranilic diamides and sulfoxaflor. The structures of the synthesized compounds were confirmed by infrared spectroscopy, 1H and 13C NMR, and elemental analysis. Several unique structural characteristics were revealed via the crystal structure analysis of compound N-(2-(2-methyl-2-(methylthio)propylcarbamoyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 16e. Bioassay results indicated that most of the synthesized compounds showed superior insecticidal activities against Mythimna separata and Plutella xylostella when compared with the positive control cyantraniliprole. In particular, N-(2-(2-methyl-2-(N-cyanomethylsulfideimino)propylcarbamoyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 17e showed excellent insecticidal activity against Mythimna separata, with a mortality rate of 100% at a concentration of 1μgmL-1. These results indicated that sulfide, N-cyanomethylsulfilimine, and N-cyanomethylsulfoximine moieties, as important active substructures, could improve or maintain the activity of the anthranilic diamide and promote novel pesticide development.

Reversible inactivation of bovine plasma amine oxidase by cysteamine and related analogs

Cysteamine (1) was reported many years ago to reversibly inhibit lentil seedling amine oxidase, through the formation of a complex with thioacetaldehyde, the turnover product of 1. Herein, cysteamine (1) and its analogs 2-(methylamino)ethanethiol (3) and 3-aminopropanethiol (6) were found to be reversible inhibitors of bovine plasma amine oxidase (BPAO), but 2-(methylthio)ethylamine (7) was determined to be a weak irreversible inhibitor of BPAO. Based on our results, indicating the necessity of a sulfhydryl-amine for reversible inactivation of BPAO, the failure of inhibited BPAO to recover activity after gel filtration, the first-order kinetics of activity recovery upon dialysis, and 2,4,6-trihydroxyphenylalanine quinine (TPQ) cofactor transformation which indicated from the results of phenylhydrazine titration and substrate protection, we propose a mechanism for the reversible inactivation of BPAO by 1 involving the formation of a cofactor adduct, thiazolidine, between BPAO and 1.