698387-93-8

Basic information

• Product Name: 2,4-Heptadienoic acid, 6-[[4-(dimethylamino)phenyl]thio]-4-methyl-, ethyl ester, (2E,4E)-
• CAS NO: 698387-93-8
• Molecular Formula: C18H25NO2S
• Molecular Weight: 319.468
• Mol File: 698387-93-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,4-Heptadienoic acid, 6-[[4-(dimethylamino)phenyl]thio]-4-methyl-, ethyl ester, (2E,4E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Heptadienoic acid, 6-[[4-(dimethylamino)phenyl]thio]-4-methyl-, ethyl ester, (2E,4E)-(698387-93-8)
• EPA Substance Registry System: 2,4-Heptadienoic acid, 6-[[4-(dimethylamino)phenyl]thio]-4-methyl-, ethyl ester, (2E,4E)-(698387-93-8)

Safety Data

• Hazardous Substances Data: 698387-93-8(Hazardous Substances Data)

Upstream product

• 1567-14-2 methyl (2E)-2-methyl-2-pentenoate 
• 16957-70-3 2-methylpent-2-enoic acid 
• 5397-29-5 4-(N,N-dimethylamino)phenyl disulfide 
• 58683-58-2 methyl (E)-4-bromo-2-methyl-2-pentenoate 
• 4946-22-9 N,N-dimethyl-4-aminothiophenol 
• 875737-07-8 methyl (E)-4-(4-dimethylaminophenylsulfanyl)-2-methyl-2-pentenoate 
• 875737-08-9 (E)-4-(4-dimethylaminophenylsulfanyl)-2-methyl-2-penten-1-ol 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Relevant articles and documents

Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides

The synthesis of a novel series of potent inhibitors of histone deacetylases is described, based on arylsulfinyl-2,4-hexadienoic acid hydroxyamicles and their derivatives. In vitro IC50 values clown to 40 nM were obtained, and several compounds showed inhibition of CEM (human leukemic) cell viability with IC50 of ～1.5 μM, comparable to or better than that of suberoylatiilide hydroxamic acid, an inhibitor of histone cleacetylase currently in clinical trials.