875737-07-8

Basic information

• Product Name: 2-Pentenoic acid, 4-[[4-(dimethylamino)phenyl]thio]-2-methyl-, methyl ester, (2E)-
• CAS NO: 875737-07-8
• Molecular Formula: C15H21NO2S
• Molecular Weight: 279.403
• Mol File: 875737-07-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Pentenoic acid, 4-[[4-(dimethylamino)phenyl]thio]-2-methyl-, methyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pentenoic acid, 4-[[4-(dimethylamino)phenyl]thio]-2-methyl-, methyl ester, (2E)-(875737-07-8)
• EPA Substance Registry System: 2-Pentenoic acid, 4-[[4-(dimethylamino)phenyl]thio]-2-methyl-, methyl ester, (2E)-(875737-07-8)

Safety Data

• Hazardous Substances Data: 875737-07-8(Hazardous Substances Data)

Upstream product

• 16957-70-3 2-methylpent-2-enoic acid 
• 4946-22-9 N,N-dimethyl-4-aminothiophenol 
• 58683-58-2 methyl (E)-4-bromo-2-methyl-2-pentenoate 

Downstream Products

• 698387-93-8 (2E,4E)-ethyl 6-(4-dimethylaminophenylsulfanyl)-4-methyl-2,4-heptadienoate 
• 875737-08-9 (E)-4-(4-dimethylaminophenylsulfanyl)-2-methyl-2-penten-1-ol 

Relevant articles and documents

Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides

The synthesis of a novel series of potent inhibitors of histone deacetylases is described, based on arylsulfinyl-2,4-hexadienoic acid hydroxyamicles and their derivatives. In vitro IC50 values clown to 40 nM were obtained, and several compounds showed inhibition of CEM (human leukemic) cell viability with IC50 of ～1.5 μM, comparable to or better than that of suberoylatiilide hydroxamic acid, an inhibitor of histone cleacetylase currently in clinical trials.