69935-12-2

Basic information

• Product Name: N-benzoyl-4-nitrophenylalanine
• CAS NO: 69935-12-2
• Molecular Formula: C₁₆H₁₄N₂O₅
• Molecular Weight: 314.2928
• Mol File: 69935-12-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 619.8°C at 760 mmHg
• Flash Point: 328.7°C
• Density: 1.364g/cm³
• Vapor Pressure: 3.18E-16mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: N-benzoyl-4-nitrophenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzoyl-4-nitrophenylalanine(69935-12-2)
• EPA Substance Registry System: N-benzoyl-4-nitrophenylalanine(69935-12-2)

Safety Data

• Hazardous Substances Data: 69935-12-2(Hazardous Substances Data)

Upstream product

• 17193-40-7 (S)-4-nitrophenylalanine methyl ester hydrochloride 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 
• 81677-60-3 (L)-p-Nitrophenylalanine methyl ester 
• 101468-97-7 N-benzoyl-(4'-nitro)phenylalanine 
• 93634-58-3 2-benzoylamino-3-(4-nitrophenyl)acrylic acid 
• 949-99-5 4-nitro-3-phenyl-L-alanine 

Downstream Products

• 934220-94-7 N-(N-benzoyl-4-nitro-L-phenylalanyl)-L-phenylalaninol 
• 934221-00-8 N-(N-benzoyl-4-nitro-L-phenylalanyl)-L-phenylalanine methyl ester 
• 934221-02-0 N-(N-benzoyl-4-nitro-L-phenylalanyl)-L-tyrosine methyl ester 
• 106942-32-9 2-phenyl-4-<(4-nitro)phenylmethyl>-5(4H)-oxazolone 

Relevant articles and documents

Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology

A thousand-fold affinity gain is achieved by introduction of a C-terminal boronic acid moiety into dipeptidic inhibitors of the Zika, West Nile, and dengue virus proteases. The resulting compounds have Ki values in the two-digit nanomolar range

Synthesis and anti-tumor activity evaluation of Matijin-Su derivatives

A series of Matijin-Su (MTS, N-(N-benzoyl-l-phenylalanyl)-O-acetyl-l- phenylalanol) derivatives was synthesized and evaluated for their anti-tumor activities in hepatocellular carcinoma cells. The IC50 of compounds 1, 3, 4, 11, 13 were less than 20 μM, and compound 1 and 3 showed an IC 50 value of less than 9 μM. Expansion inhibition could be found significantly in compound 1 and 3-treated human hepatoma cell HepG2 and PLC/PRF/5, while both compounds exhibit lower toxicity to human hepatocyte cell line L-02. Compound 1 and 3 could induce cell cycle arrest at G1/S phase. This may be attributed to increase level of intracellular reactive oxygen species (ROS). Up-regulation of p38 MAPK activity in responding the ROS stabilize p53 and activate p21 transcription, the critical regulatory in G1/S checkpoint. Observations in this study shed light on the potential of MTS derivatives compound 1 and 3 as novel suppressors to human liver cancer.

UNUSUAL AMINO ACIDS. III. ASYMMETRIC SYNTHESIS OF 3-ARYLALANINES

21 (Z)-α-N-benzoylamino-β-arylacrylic acids and their esters were prepared by known procedures and hydrogenated to the corresponding optically active α-benzoyl-β-arylalanine derivatives with optical yields in the range of 82-95percent ee using the cationi