70021-34-0

Basic information

• Product Name: D-Glucuronic acid
• CAS NO: 70021-34-0
• Molecular Weight: 194.141
• Mol File: 70021-34-0.mol
• Article Data: 147

Chemical Properties

• CAS DataBase Reference: D-Glucuronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: D-Glucuronic acid(70021-34-0)
• EPA Substance Registry System: D-Glucuronic acid(70021-34-0)

Safety Data

• Hazardous Substances Data: 70021-34-0(Hazardous Substances Data)

Upstream product

• 72671-87-5 O-α-glucosyluronic acid α-D-glucosiduronic acid 
• 106623-54-5 1-[(α-methyl)phenyl]acetyl-β-D-glucopyranuronic acid 
• 6294-16-2 D-galacturonic acid 
• 902141-54-2 di(D-galactosiduronic) acid 
• 18486-47-0 methyl D-galactopyranuronate 
• 79154-52-2 sepositoside A 
• 77521-62-1 C₄₁H₆₄O₁₃ 
• 59252-95-8 <α-L-arabinofuranosyl-(1-> 4)-β-D-glucuronopyranosyl-(1-> 3)>-3β-hydroxyolean-12-en-28-oic acid 
• 2479-90-5 Estrone O₃-glucuronide 
• 22688-79-5 quercetin 3-O-β-D-glucuronopyranoside 
• 26020-14-4 calenduloside E 
• 71484-85-0 p-nitrophenyl-O-α-D-glucosiduronic acid 
• 22688-78-4 kaempferol 3-O-β-D-glucuronide 
• 2280-44-6 D-Glucose 

Downstream Products

• 5155-54-4 methyl (methyl α-D-galacturonopyranoside)uronate 
• 18486-38-9 methyl β-D-glucuronopyranoside methyl ester 
• 133640-39-8 methyl α,β-D-glucopyranosidurono-6,3-lactone 
• 17681-01-5 methyl β-D-glucofuranosidurono-6,3-lactone 
• 17681-01-5 methyl α-D-glucofuranosidurono-6,3-lactone 
• 18486-51-6 1-O-methyl-α-D-glucopyranuronic acid methyl ester 
• 109923-93-5 phenylmethyl (phenylmethyl α-D-galactopyranosid)uronate 
• 62133-77-1 1,2,3,4-tetra-O-acetyl-β-D-glucopyranuronic acid 
• 83023-73-8 (2S,3S,4S,5R,6R)-3,4,5,6-tetraacetoxytetrahydro-2H-pyran-2-carboxylic acid 
• 153321-67-6 Retinoic Acid glucuronide 
• 203632-28-4 (2S,3R,4S,5R)-6-Benzyloxy-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid benzyl ester 
• 239083-75-1 D-galacturonic acid (E)-2-nitrophenylhydrazone 
• 147-73-9 meso-tartaric acid 
• 728879-26-3 D-arabinuronic acid 

Relevant articles and documents

Application of bacterial directed enzyme prodrug therapy as a targeted chemotherapy approach in a mouse model of breast cancer

Cancer is the second leading cause of death in the world. Some of the usual cancer treatments include surgery, chemotherapy, and radiotherapy. However, due to low efficacy and side effects of these treatments, novel targeted therapeutic methods are needed. One of the common drawbacks of cancer chemotherapy is off-target toxicity. In order to overcome this problem, many investigations have been conducted. One of the new targeted therapy methods known as bacterial directed enzyme-prodrug therapy (BDEPT) employs bacteria as enzyme carriers to convert a pro-drug to a drug specifically within the tumor site. In the present study, we used Escherichia coli DH5α carrying luxCDABE gene cluster and overexpressing β-glucuronidase for luminescent emission and enzyme expression, respectively. Enzyme expression can lead to the conversion of glycyrrhizic acid as a prodrug to glycyrrhetinic acid, a potent anti-cancer agent. DH5α-lux/βG was characterized and its stability was also evaluated. Bacteria colonization in the tumor site was measured by tissue homogenate preparation and colony counting method. Histopathological studies on the liver, spleen, and tumor were also conducted. According to the results, co-treatment of 4T1, a highly metastatic mouse breast cancer cell line, with GL and DH5α-lux/βG could significantly decrease the IC50 values. Moreover, increased number of bacteria could lead to a dramatic drop in IC50 value. Specific colonization of DH5α-lux/βG was observed in the tumor site compared with other tissues (p 0.0001). Moreover, the biocompatibility evaluation proved that DH5α-lux/βG had no adverse effects on normal tissues. Furthermore, concurrent usage of GL and bacteria in the treatment of induced 4T1 tumors in BALB/c mice significantly delayed tumor growth (p0.001) during 16 days of investigation. Based on these findings, BDEPT might be useful for targeted breast cancer therapy, although further investigations are required to confirm this.

Apigenin Glycosides from Astragalus galegiformis

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A novel acylated flavonol tetraglycoside and rare oleanane saponins with a unique acetal-linked dicarboxylic acid substituent from the xero-halophyte Bassia indica

In recent years, the scientific interest and particularly the economic significance of halophytic plants has been highly demanding due to the medicinal and nutraceutical potential of its bioactive compounds. A xero-halophyte Bassia indica is deemed to be