72141-41-4

Basic information

• Product Name: (4-NITRO-PHENYL)-PIPERAZIN-1-YL-METHANONE
• Synonyms: AKOS BB-6408;(4-NITRO-PHENYL)-PIPERAZIN-1-YL-METHANONE;(4-NITROPHENYL)(PIPERAZINO)METHANONE;1-(4-NITROBENZOYL)-PIPERAZINE;BUTTPARK 153\33-43
• CAS NO: 72141-41-4
• Molecular Formula: C₁₁H₁₃N₃O₃
• Molecular Weight: 235.24
• Product Categories: piperazines
• Mol File: 72141-41-4.mol
• Article Data: 28

Chemical Properties

• Melting Point: 158-161°C
• Boiling Point: 443.9°C at 760 mmHg
• Flash Point: 222.2°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 4.48E-08mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.24±0.10(Predicted)
• CAS DataBase Reference: (4-NITRO-PHENYL)-PIPERAZIN-1-YL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-NITRO-PHENYL)-PIPERAZIN-1-YL-METHANONE(72141-41-4)
• EPA Substance Registry System: (4-NITRO-PHENYL)-PIPERAZIN-1-YL-METHANONE(72141-41-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 72141-41-4(Hazardous Substances Data)

Usage

General Description

"(4-Nitro-Phenyl)-Piperazin-1-yl-Methanone" is a chemical compound notable for its unique structure. This organic compound is characterized by a central methanone group bonded to a piperazine ring, with a nitrophenyl group positioned at the 4th carbon of the ring. The presence of the nitro group and piperazine suggests that it can potentially be used in the synthesis of various pharmaceutical drugs. However, specific information about its physical properties, toxicity, and applications is not widely available, indicating that it is likely primarily used in research settings and is not commonly found in everyday products or applications.

InChI:InChI=1/C11H13N3O3/c15-11(13-7-5-12-6-8-13)9-1-3-10(4-2-9)14(16)17/h1-4,12H,5-8H2

Upstream product

• 110-85-0 piperazine 
• 7622-07-3 2,4-dinitrophenyl p-nitrobenzoate 
• 122-04-3 4-nitro-benzoyl chloride 
• 1037-31-6 4-nitrophenyl 4-nitrobenzoate 
• 78823-40-2 pivalic p-nitrobenzoic anhydride 
• 62-23-7 4-nitro-benzoic acid 
• 69737-96-8 S-(p-nitrophenyl) p-nitrothiobenzoate 
• 35612-14-7 S-2,4-dinitrophenyl 4-nitrothiobenzoate 
• 22044-09-3 piperazinium 
• 10364-96-2 N-(4-nitrobenzoyl)imidazole 
• 142-64-3 piperazine dihydrochloride 
• 5366-37-0 4-nitrobenzoic acid 2-pyridinyl ester 
• 636-98-6 p-nitrobenzene iodide 
• 13939-06-5 molybdenum hexacarbonyl 

Downstream Products

• 1075248-10-0 C₂₁H₁₇N₃O₆ 
• 1622867-09-7 C₂₅H₂₁N₅O₅S 
• 462616-51-9 C₁₄H₁₉N₃O₃ 
• 892495-32-8 2-[4-(4-nitrobenzoyl)-1-piperazinomethyl]-3,5,6-trimethylpyrazine 
• 329003-81-8 (4-amino-phenyl)-{4-[2-(4-amino-phenyl)-ethyl]-piperazin-1-yl}-methanone 

Relevant articles and documents

Solar and visible-light active nano Ni/g-C3N4photocatalyst for carbon monoxide (CO) and ligand-free carbonylation reactions

In this study, we investigate the amino and alkoxycarbonylation reaction between various substituted aryl halides, benzyl iodides, and iodocyclohexane with different types of amines and alcohols in the absence of carbon monoxide gas and ligands. Similar reactions are carried out at high temperatures, in the presence of appropriate ligands, stoichiometric amounts of bases, and gaseous carbon monoxide, which endanger the health of organic chemists. We present a novel method that does not utilize ligands, bases, gaseous CO, and special conditions. This procedure is a redox reaction carried out by new economic nano Ni/g-C3N4at room temperature and under visible light. Mo(CO)6was used toin situgenerate CO, to resolve the problems caused by the use of CO gas. This protocol has the ability to be used on a gram scale by using a continuous flow reactor.

Application of substituted o-hydroxybenzophenone compound or pharmaceutically acceptable salt thereof to preparation of drug for treating neurodegenerative disease

The invention discloses application of a substituted o-hydroxybenzophenone compound or a pharmaceutically acceptable salt thereof to preparation of a drug for treating a neurodegenerative disease. Thestructure of the compound is shown in a formula I; in t

N?-Acryloyllysine Piperazides as Irreversible Inhibitors of Transglutaminase 2: Synthesis, Structure-Activity Relationships, and Pharmacokinetic Profiling

Transglutaminase 2 (TGase 2)-catalyzed transamidation represents an important post-translational mechanism for protein modification with implications in physiological and pathophysiological conditions, including fibrotic and neoplastic processes. Consequently, this enzyme is considered a promising target for the diagnosis of and therapy for these diseases. In this study, we report on the synthesis and kinetic characterization of N?-acryloyllysine piperazides as irreversible inhibitors of TGase 2. Systematic structural modifications on 54 new compounds were performed with a major focus on fluorine-bearing substituents due to the potential of such compounds to serve as radiotracer candidates for positron emission tomography. The determined inhibitory activities ranged from 100 to 10?000 M-1 s-1, which resulted in comprehensive structure-activity relationships. Structure-activity correlations using various substituent parameters accompanied by covalent docking studies provide an advanced understanding of the molecular recognition for this inhibitor class within the active site of TGase 2. Selectivity profiling of selected compounds for other transglutaminases demonstrated an excellent selectivity toward transglutaminase 2. Furthermore, an initial pharmacokinetic profiling of selected inhibitors was performed, including the assessment of potential membrane permeability and liver microsomal stability.