72482-15-6

Basic information

• Product Name: 3-Chloro-4-Methoxysalicylaldehyde
• Synonyms: 3-Chloro-4-Methoxysalicylaldehyde;3-chloro-2-hydroxy-4-methoxyBenzaldehyde
• CAS NO: 72482-15-6
• Molecular Formula: C₈H₇ClO₃
• Molecular Weight: 186.59238
• Mol File: 72482-15-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 275.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.377±0.06 g/cm3(Predicted)
• PKA: 6.32±0.15(Predicted)
• CAS DataBase Reference: 3-Chloro-4-Methoxysalicylaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-Methoxysalicylaldehyde(72482-15-6)
• EPA Substance Registry System: 3-Chloro-4-Methoxysalicylaldehyde(72482-15-6)

Safety Data

• Hazardous Substances Data: 72482-15-6(Hazardous Substances Data)

Usage

Description

3-Chloro-4-Methoxysalicylaldehyde is a chemical compound characterized by the molecular formula C8H7ClO3. It is a white to light yellow solid that exhibits solubility in organic solvents. 3-Chloro-4-Methoxysalicylaldehyde is distinguished by its versatile reactivity and unique properties, which make it a valuable component in various industrial applications.

Uses

Used in Organic Synthesis:
3-Chloro-4-Methoxysalicylaldehyde is utilized as a reagent in organic synthesis, playing a crucial role in the formation of complex organic molecules. Its unique structure allows it to participate in a variety of chemical reactions, facilitating the synthesis of desired products.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 3-Chloro-4-Methoxysalicylaldehyde serves as an intermediate. It is involved in the synthesis of various drugs, contributing to the development of new medications and therapeutic agents.
Used in Agrochemical Production:
3-Chloro-4-Methoxysalicylaldehyde is also employed as an intermediate in the production of agrochemicals. Its incorporation aids in the development of agricultural products, such as pesticides and herbicides, which are essential for maintaining crop health and productivity.
Used in Dye and Pigment Manufacturing:
3-Chloro-4-Methoxysalicylaldehyde finds application in the creation of dyes and pigments, where it contributes to the coloration and stability of these products. Its use in this industry highlights its potential in creating a diverse range of colors and shades.
Used in Medicine:
3-Chloro-4-Methoxysalicylaldehyde has potential applications in the medical field, where its unique properties can be harnessed for the development of new treatments and therapies.
Used in Agriculture:
In agriculture, this compound can be utilized to develop more effective and targeted agrochemicals, enhancing crop protection and yield.
Used in Materials Science:
3-Chloro-4-Methoxysalicylaldehyde's potential in materials science lies in its ability to contribute to the development of new materials with improved properties, such as enhanced stability or specific reactivity.
It is important to handle 3-Chloro-4-Methoxysalicylaldehyde with care due to its potential harmful effects if not properly managed, ensuring safety in all applications.

Upstream product

• 6201-65-6 2-chlororesorcinol 
• 50-00-0 formaldehyd 
• 72232-49-6 2-chloro-3-methoxyphenol 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 7051-15-2 2-chlororesorcinol dimethyl ether 
• 72482-14-5 3-chloro-2,4-dimethoxybenzaldehyde 

Downstream Products

• 90247-27-1 (R)-3-[(S)-8-Chloro-3-(2-fluoro-phenyl)-5,6-dihydro-furo[2',3':4,5]benzo[1,2-d]isoxazole-6-carbonyl]-4-phenyl-oxazolidin-2-one 
• 90247-26-0 (R)-3-[(R)-8-Chloro-3-(2-fluoro-phenyl)-5,6-dihydro-furo[2',3':4,5]benzo[1,2-d]isoxazole-6-carbonyl]-4-phenyl-oxazolidin-2-one 
• 90247-30-6 (S)-8-Chloro-3-(2-fluoro-phenyl)-5,6-dihydro-furo[2',3':4,5]benzo[1,2-d]isoxazole-6-carboxylic acid 
• 90247-29-3 (R)-8-Chloro-3-(2-fluoro-phenyl)-5,6-dihydro-furo[2',3':4,5]benzo[1,2-d]isoxazole-6-carboxylic acid 
• 90247-08-8 8-chloro-3-(2-fluorophenyl)-5,6-dihydrofuro[3,2-f]-1,2-benzisoxazole-6-carboxylic acid 
• 90246-99-4 ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate O-acetyloxime 
• 90246-88-1 ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate oxime 
• 90246-98-3 ethyl 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxylate 
• 90246-78-9 ethyl 7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate 
• 90247-25-9 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo<3,2-f>-1,2-benzisoxazole-6-carbonyl chloride 
• 90247-23-7 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxamide 
• 90247-24-8 8-chloro-6-cyano-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxamide 

Relevant articles and documents

TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF

The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

2,2,6,6-Tetramethylpiperidine-catalyzed, ortho-selective chlorination of phenols by sulfuryl chloride

2,2,6,6-Tetramethylpiperidine (TMP)-catalyzed (1- 10%) chlorinations of phenols by SO2Cl2 in aromatic solvents are more ortho selective than with primary and less hindered secondary amine catalysts. Ortho-selective chlorination is successful even with electron deficient phenols such as 2-hydroxybenzaldehyde and 2'- hydroxyacetophenone. Notably, ortho selectivity increases with the reaction temperature. On the other hand, tetraalkylammonium chloride-catalyzed chlorinations are moderately para selective.

1,2-benzisoxazoloxyacetic acids and related compounds

Novel 1,2-benzisoxazoloxyacetic acids and related compounds, methods for preparing same and methods of treatment by administering compositions containing such a compound are described. These compounds are useful as diuretic, uricosuric and antihypertensive agents.