7364-51-4

Basic information

• Product Name: N-(Trimethylsilyl)-L-phenylalanine trimethylsilyl ester
• Synonyms: N-(Trimethylsilyl)-L-phenylalanine trimethylsilyl ester;TMS-L-phenylalanine;Trimethylsilyl-L-phenylalanine
• CAS NO: 7364-51-4
• Molecular Formula: C₁₅H₂₇NO₂Si₂
• Molecular Weight: 309.55
• Mol File: 7364-51-4.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(Trimethylsilyl)-L-phenylalanine trimethylsilyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(Trimethylsilyl)-L-phenylalanine trimethylsilyl ester(7364-51-4)
• EPA Substance Registry System: N-(Trimethylsilyl)-L-phenylalanine trimethylsilyl ester(7364-51-4)

Safety Data

• Hazardous Substances Data: 7364-51-4(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 63-91-2 L-phenylalanine 
• 7677-24-9 trimethylsilyl cyanide 
• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 

Downstream Products

• 852866-04-7 Fmoc-Phg-Phe-OH 
• 852866-05-8 Fmoc-D-Phg-Phe-OH 
• 1051456-53-1 Boc-Val-ψ(NH-CO-NH)-Phe-OH 
• 114457-94-2 (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid 
• 1621908-78-8 ((R)-1-((S)-2-acetamido-3-phenylpropanamido)-3-methylbutyl)boronic acid 
• 179324-79-9 ((R)-1-((S)-2-benzamido-3-phenylpropanamido)-3-methylbutyl)boronic Acid 
• 1621908-76-6 N-((S)-1-(((R)-3-methyl-1-((3aR,4R,6R,7aS)-5,5,7a-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)benzamide 
• 2018-61-3 (S)-2-acetylamino-3-phenylpropanoic acid 
• 2566-22-5 N-benzoyl-L-phenylalanine 
• 1621908-72-2 N-[(1S)-1-[[[(1R)-1-[(3aS,4R,6R,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-amino]carbonyl]-2-phenyl]-2-pyrazincarboxamide 
• 117370-45-3 (9-fluorenylmethyloxycarbonyl)glycyl-L-phenylalanine 
• 1238891-60-5 C₂₄H₂₄N₂O₄Si 
• 1238891-59-2 C₁₉H₂₂N₂O₄Si 
• 79137-83-0 N-Mesitoyl-α-(3-oxohexyl)phenylalanin 

Relevant articles and documents

Bortezomib congeners induce apoptosis of hepatocellular carcinoma via CIP2A inhibition

CIP2A is an oncoprotein that upregulates p-Akt and promotes cancer cell proliferation and survival. The proteasome inhibitor bortezomib has been shown to reduce CIP2A and lead to cell apoptosis. Here; we modified the functional group of bortezomib to generate a series of novel compounds and conducted a structure-activity relationship (SAR) study. The results showed that compound 1 was able to repress CIP2A expression and cell apoptosis in the same manner as bortezomib, but with less potency in inhibition of proteasome activity. This finding provides a new direction for the design of CIP2A inhibitors.

Simple and rapid synthesis of Nα-urethane protected β-amino alcohols and peptide alcohols employing HATU

The activation of the Nα--urcihanc protected (Fmoc-/Boc-/Z-/Bsmoc) α-amino acids employing l-[bis(dimethylamino)- methylene]-lH-l,2,3-triazolo-[4,5-6]pyridinium.0hexa-flurophosphate-3-oxide (HATU) followed by reduction of the in situ generated -OAt ester with NaBH 4 results in the corresponding ss-amino alcohols in good yields. This synthesis is the first demonstration of the application of the efficient coupling agent HATU for practical synthesis of ss-amino alcohols. The protocol is general for all common N-protecting groups including the highly base sensitive Bsmoc group. The protocol has also been successfully extended for the synthesis of peptide alcohols.

HOBt·DCHA-mediated synthesis of sterically hindered peptides employing Fmoc-amino acid chlorides in both solution-phase and solid phase methods

The synthesis of peptides employing Fmoc-amino acid chlorides in presence of HOBt·DCHA salt in solution as well as by the solid-phase methods is described. The coupling was found to be complete in 30 min and free from racemization. The synthesis of β-casomorphin by solid-phase protocol employing Fmoc-amino acid chloride/HOBt·DCHA in DMF-CH2Cl2 has also been outlined. The final peptide was obtained in 80% yield and was fully characterized. Copyright Taylor & Francis Group, LLC.