852866-05-8

Basic information

• Product Name: Fmoc-D-Phg-Phe-OH
• Synonyms: Fmoc-D-Phg-Phe-OH
• CAS NO: 852866-05-8
• Molecular Weight: 520.585
• Mol File: 852866-05-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Fmoc-D-Phg-Phe-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-D-Phg-Phe-OH(852866-05-8)
• EPA Substance Registry System: Fmoc-D-Phg-Phe-OH(852866-05-8)

Safety Data

• Hazardous Substances Data: 852866-05-8(Hazardous Substances Data)

Upstream product

• 7364-51-4 N,O-bis(trimethylsilyl)phenylalanine 
• 111524-97-1 Fmoc-D-Phg-Cl 
• 63-91-2 L-phenylalanine 
• 111524-95-9 N-Fmoc-D-phenylglycine 

Downstream Products

• 938464-46-1 Fmoc-D-Phg-Phe-N₃ 

Relevant articles and documents

Simple and rapid synthesis of Nα-urethane protected β-amino alcohols and peptide alcohols employing HATU

The activation of the Nα--urcihanc protected (Fmoc-/Boc-/Z-/Bsmoc) α-amino acids employing l-[bis(dimethylamino)- methylene]-lH-l,2,3-triazolo-[4,5-6]pyridinium.0hexa-flurophosphate-3-oxide (HATU) followed by reduction of the in situ generated -OAt ester with NaBH 4 results in the corresponding ss-amino alcohols in good yields. This synthesis is the first demonstration of the application of the efficient coupling agent HATU for practical synthesis of ss-amino alcohols. The protocol is general for all common N-protecting groups including the highly base sensitive Bsmoc group. The protocol has also been successfully extended for the synthesis of peptide alcohols.

Synthesis of Fmoc-protected β-amino alcohols and peptidyl alcohols from Fmoc-amino acid/peptide acid azides

An efficient synthesis of Nα-9H-fluoren-9- ylmethoxycarbony(Fmoc)-β-amino alcohols by the reduction of Fmoc-α-amino acyl azides employing aqueous NaBH4 as a reducing agent has been described. The reduction is found to be simple and almost complete. All the Fmoc-β-amino alcohols prepared are fully characterized by 1H and 13C NMR and mass spectrometry. Further, the method is extended for the reduction of seven Fmoc-dipeptidyl acids to the corresponding alcohols. Their reduction is also found to be smooth and complete.