73994-88-4

Basic information

• Product Name: L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-, phenylmethyl ester
• CAS NO: 73994-88-4
• Molecular Formula: C29H39N3O6
• Molecular Weight: 525.645
• Mol File: 73994-88-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-, phenylmethyl ester(73994-88-4)
• EPA Substance Registry System: L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-L-phenylalanyl]-, phenylmethyl ester(73994-88-4)

Safety Data

• Hazardous Substances Data: 73994-88-4(Hazardous Substances Data)

Upstream product

• 3674-06-4 Boc-Phe-ONSu 
• 1738-77-8 L-leucine benzyl ester p-toluenesulfonate 
• 3392-07-2 tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate 
• 73994-87-3 (S)-benzyl 2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanoate hydrochloride 
• 71027-08-2 (S)-4-Methyl-2-[(S)-2-(2-nitro-phenylsulfanylamino)-3-phenyl-propionylamino]-pentanoic acid benzyl ester 
• 74193-68-3 N-tert-butyloxycarbonyl-L-phenylalanyl-L-leucine benzyl ester 
• 1738-69-8 L-Leucine benzyl ester 
• 4530-20-5 BOC-glycine 
• 3655-05-8 tert-butoxycarbonylglycine p-nitrophenylester 
• 63649-15-0 L-phenylalanyl-L-leucine benzyl ester 
• 56406-63-4 N-(tert-butoxycarbonyl)glycine succinimide ester 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 77066-56-9 benzyl-L-penylalanyl-L-leucinate trifluoroacetic acid 

Downstream Products

• 69729-14-2 benzyl ester of N-tert-butoxycarbonylglycylglycylphenylalanylleucine 
• 66328-74-3 Boc-Gly-Phe-Leu-OH 
• 77511-32-1 5>-enkephalin 
• 64963-27-5 N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine 
• 63986-20-9 HCl·H-Tyr(OH)-Gly-Gly-Phe-Leu-OH 
• 948314-83-8 Leu⁵-Eukephalin 
• 69729-07-3 H-Gly-Gly-Phe-Leu-OBzl 
• 112550-44-4 Gly-Phe-Leu-Thr-O-Bzl, TFA 
• 81184-10-3 HCl*H-Gly-Phe-Leu-OBzl 
• 73994-89-5 (S)-benzyl 2-((S)-2-(2-aminoacetamido)-3-phenylpropanamido)-4-methylpentanoate 
• 98695-49-9 Cbz-Tyr(Bzl)-β(BzlO)Ala-Gly-Phe-Leu-OBzl 
• 98695-47-7 Cbz-Tyr(Bzl)-(BzlO)Gly-Gly-Phe-Leu-OBzl 
• 98695-48-8 Cbz-Tyr(Bzl)-(BzlO)Ala-Gly-Phe-Leu-OBzl 
• 109022-57-3 H-(BzlO)Val-Gly-Phe-Leu-OBzl 

Relevant articles and documents

Method of producing peptide

The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active

Preparation and conformational study of CF3-containing enkephalin-derived oligopeptide

Incorporation of (2S,3S)-4,4,4-trifluorothreonine (F3-Thr) instead of Thr in the enkephalin-derived hexapeptide led to the apparent conformational alteration due to the strong electron-withdrawing effect of the trifluoromethyl group by comparison with the original compound on the basis of their various NMR measurements.

MW-enhanced high-speed deprotection of Boc group using p-TsOH and concommitant formation of N-Me-amino acid benzyl ester p-TsOH salts

A high-speed, complete deprotection of Boc group from Boc amino acids and protected peptide esters employing p-TsOH in toluene under microwave irradiation is found to be complete in 30s. The deprotection can be carried out in methanol and acetonitrile also. Under the present conditions, C-peptide benzyl esters and O-benzyl ethers have been found to be stable. This has permitted us to carry out the synthesis of [Leu]enkephalin employing the Boc/Bzl-group strategy. Further more, it has been found that both Nα-Fmoc and N α-Z groups are completely stable. The present conditions can be extended for the concomitant removal of the Boc group and the formation of C-benzyl amino acid esters as well. This has been utilized for the synthesis of N-Me amino acid benzyl esters starting from Boc-N-Me amino acids in a single step. Copyright Taylor & Francis, Inc.