74746-10-4

Basic information

• Product Name: Ethanone, 1-(2-bromo-4,5-dimethoxyphenyl)-
• CAS NO: 74746-10-4
• Molecular Formula: C10H11BrO3
• Molecular Weight: 259.1
• Mol File: 74746-10-4.mol
• Article Data: 28

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(2-bromo-4,5-dimethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-bromo-4,5-dimethoxyphenyl)-(74746-10-4)
• EPA Substance Registry System: Ethanone, 1-(2-bromo-4,5-dimethoxyphenyl)-(74746-10-4)

Safety Data

• Hazardous Substances Data: 74746-10-4(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(2-bromo-4,5-dimethoxyphenyl)- is a chemical compound that belongs to the ketone class. It contains a bromine atom and two methoxy groups attached to a phenyl ring. Ethanone, 1-(2-bromo-4,5-dimethoxyphenyl)- is commonly used in organic synthesis and pharmaceutical research as a building block for producing various products. Its structure and properties make it suitable for applications in drug discovery, medicinal chemistry, and materials science. However, it is important to handle this chemical with care due to its potential hazards and reactivity.

Upstream product

• 5293-52-7 6-bromo-3,4-dimethoxy-α-methylbenzyl alcohol 
• 89978-46-1 4-bromo-5-iodoveratrole 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 676-58-4 methylmagnesium chloride 
• 55171-61-4 2-bromo-4,5-dimethoxybenzoyl chloride 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 75-16-1 methylmagnesium bromide 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 

Downstream Products

• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 151694-58-5 2-methyl-2-(2-bromo-4,5-dimethoxyphenyl)-1,3-oxathiolane 
• 162755-99-9 1-(2-Bromo-4,5-dimethoxyphenyl)-1-(trimethylsiloxy)ethylene 
• 910136-50-4 4,5-dimethoxy-2-(2-trimethylsilylethynyl)acetophenone 
• 1233979-74-2 (Z)-N'-[1-(2-bromo-4,5-dimethoxyphenyl)ethylidene]-4-methylbenzenesulfonohydrazide 
• 1233979-79-7 5,6-dimethoxy-3-methyl-1-(p-tolylsulfonyl)indazole 
• 1215858-80-2 2-bromo-1-(2-bromo-4,5-dimethoxyphenyl)ethanone oxime 
• 1616606-35-9 C₁₄H₁₉BrN₂O₃ 
• 1609071-67-1 C₁₄H₁₈N₂O₃ 
• 1616667-69-6 ethyl (2E)-3-(2-bromo-4,5-dimethoxyphenyl)but-2-enoate 
• 1432493-85-0 C₁₂H₁₅BrO₃ 
• 1432493-90-7 C₁₂H₁₅BrO₃ 
• 1394840-69-7 C₁₅H₁₁BrO₅ 
• 1394840-98-2 C₁₉H₁₉BrO₅ 

Relevant articles and documents

α-Oxocarboxylic Acids as Three-Carbon Insertion Units for Palladium-Catalyzed Decarboxylative Cascade Synthesis of Diverse Fused Heteropolycycles

A novel palladium-catalyzed decarboxylative cascade cyclization for the assembly of diverse fused heteropolycycles by employing α-oxocarboxylic acids as three-carbon insertion units is reported. This protocol enables the synthesis of isoquinolinedione- and indolo[2,1-a]isoquinolinone-fused benzocycloheptanones in moderate to good yields by the use of different aryl iodides, including alkene-tethered 2-iodobenzamides and 2-(2-iodophenyl)-1H-indoles. Notably, the approach achieves simultaneous construction of both six- and seven-membered rings via sequential intramolecular carbopalladation, C-H activation, and decarboxylation.

Annulative Morita-Baylis-Hillman reaction to synthesise chiral dibenzocycloheptanes

We describe the first metal-free and organocatalytic strategy to access highly functionalised dibenzocycloheptanesviaa phosphine-promoted annulative Morita-Baylis-Hillman (MBH) reaction. The method is manipulated to access to chiral dibenzocycloheptanes as well. This work represents a rare entry for the construction of seven-membered carbocyclesviathe MBH route. The realisation of several bioactive molecules possessing the dibenzocycloheptane core makes this an attractive strategy.

Asymmetric Synthesis of 1,2-Dihydronaphthalene-1-ols via Copper-Catalyzed Intramolecular Reductive Cyclization

We describe a copper-catalyzed intramolecular reductive cyclization of easily accessible benz-tethered 1,3-dienes containing a ketone moiety. This process provided biologically active 1,2-dihydronaphthalene-1-ol derivatives in good yields with excellent enantio- and diastereoselectivity. Mechanistic investigations using density functional theory revealed that (Z)- and (E)-allylcopper intermediates formed in situ from the diene and copper catalyst undergo isomerization and selective intramolecular allylation of the (E)-allylcopper form of the major product through a six-membered boatlike transition state. The resulting products were further transformed to fully saturated naphthalene-1-ols by reactions of the olefin moiety.