75541-86-5

Basic information

• Product Name: Benzoic acid, 2-[(4-nitrobenzoyl)amino]-, methyl ester
• CAS NO: 75541-86-5
• Molecular Formula: C15H12N2O5
• Molecular Weight: 300.271
• Mol File: 75541-86-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-[(4-nitrobenzoyl)amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[(4-nitrobenzoyl)amino]-, methyl ester(75541-86-5)
• EPA Substance Registry System: Benzoic acid, 2-[(4-nitrobenzoyl)amino]-, methyl ester(75541-86-5)

Safety Data

• Hazardous Substances Data: 75541-86-5(Hazardous Substances Data)

Upstream product

• 62-23-7 4-nitro-benzoic acid 
• 134-20-3 2-carbomethoxyaniline 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 693241-54-2 2-(4'-(2''-methoxybenzamido)benzamido)benzoic acid 
• 6345-04-6 N-(4-nitrobenzoyl)anthranilic acid 
• 180133-07-7 methyl 2-(4-aminobenzamido)benzoate 
• 16063-05-1 2-(4-nitrophenyl)-4H-3,1-benzoxazin-4-one 

Relevant articles and documents

Asymmetric Synthesis of N-N Axially Chiral Compounds by Phase-Transfer-Catalyzed Alkylations

N-N axially chiral skeletons are significant structural motifs in natural products, pharmaceuticals, and functional materials. Herein we disclose a method for the asymmetric synthesis of N-N axially chiral compounds by phase-transfer catalysis. A wide range of N-N axially chiral quinazolinone derivatives were prepared in high yields with excellent stereoselectivities. Furthermore, the synthetic utility of the protocol was proved by large-scale reaction and transformation of the product. Density functional theory calculations provide insight into the mechanism.

Synthesis of some new glutamine linked 2,3-disubstituted quinazolinone derivatives as potent antimicrobial and antioxidant agents

A series of novel glutamine linked 2,3-disubstituted quinazolinone conjugates was synthesized from methyl anthranilate and different substituted acids and acid chlorides. The compounds 5a-l were prepared in good yields. All compounds were screened for their antibacterial activity against Gram-positive and Gram-negative bacteria and for antifungal activity against Candida albicans and Aspergillus flavus using paper disk diffusion technique. The minimum inhibitory concentrations of the compounds were also determined by agar streak dilution method. The compound 5b was found to exhibit the most potent in vitro anti-microbial activity. When tested for their antioxidant activity, compounds 5i and 5l showed potent radical scavenging activity, while compound 5g had moderate effect against 2,2-diphenyl-1-picrylhydrazyl, hydroxyl, nitric oxide, and superoxide radical scavenging assays. These results suggest that, the three quinazolinone analogs (5g, 5i, and 5l) could be considered as useful templates for future development to obtain more potent antioxidant agents.

Substituted cyclic amine compound, production process thereof and pharmaceutical composition for circulatory organ use containing the same

A substituted cyclic amine compound represented by the following general formula (1) STR1 wherein each of R1 to R5 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or the like, A represents a carbonyl group or a sulfonyl group, B represents a methine moiety or a nitrogen atom, D represents a methine moiety, a nitrogen atom or =N(→O)-- and n is an integer of 2 to 3; and synthetic methods thereof. The inventive compound is useful in preventing and treating circulatory organ-related diseases such as hypertension, ischemic heart disease, cerebrovascular disease, peripheral circulatory disease and the like.