16063-05-1

Basic information

• Product Name: 2-(4-Nitrophenyl)-4H-3,1-benzoxazin-4-one
• Synonyms: 2-(4-Nitrophenyl)-4H-3,1-benzoxazin-4-one
• CAS NO: 16063-05-1
• Molecular Formula: C₁₄H₈N₂O₄
• Molecular Weight: 268.22
• Mol File: 16063-05-1.mol
• Article Data: 31

Chemical Properties

• Melting Point: 190 °C
• Boiling Point: 428.7±24.0 °C(Predicted)
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• PKA: 1.05±0.20(Predicted)
• CAS DataBase Reference: 2-(4-Nitrophenyl)-4H-3,1-benzoxazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Nitrophenyl)-4H-3,1-benzoxazin-4-one(16063-05-1)
• EPA Substance Registry System: 2-(4-Nitrophenyl)-4H-3,1-benzoxazin-4-one(16063-05-1)

Safety Data

• Hazardous Substances Data: 16063-05-1(Hazardous Substances Data)

Usage

Class

Benzoxazinone derivatives

Functional group

Nitrophenyl group

Potential applications

Pharmaceuticals, agrochemicals, materials science

Possible properties

Biological activities

Usage

Building block in the synthesis of other organic compounds

Importance

Promising candidate for research and development in the chemical industry

Structural and physicochemical properties

Influence its potential applications and further research

Upstream product

• 6345-04-6 N-(4-nitrobenzoyl)anthranilic acid 
• 118-92-3 anthranilic acid 
• 122-04-3 4-nitro-benzoyl chloride 
• 62-23-7 4-nitro-benzoic acid 
• 75541-86-5 2-(4-nitrobenzoylamino)benzoic acid methyl ester 
• 5344-90-1 2-Aminobenzyl alcohol 
• 555-16-8 4-nitrobenzaldehdye 
• 82085-89-0 2-(4'-nitrophenyl)-1,2-dihydro-4H-3,1-benzoxazine 
• 196085-87-7 2-(4-nitro-phenyl)-4H-benzo[d][1,3]oxazine 
• 144294-91-7 3-hydroxy-2-(4-nitrophenyl)-4-oxo-1,4-dihydroquinoline 
• 134-20-3 2-carbomethoxyaniline 
• 88-67-5 2-Iodobenzoic acid 
• 619-72-7 4-nitrobenzonitrile 
• 7409-30-5 p-nitrobenzylamine 

Downstream Products

• 52910-89-1 2-(4-Nitrobenzamido)benzamide 
• 61335-19-1 4-[2-(4-nitro-phenyl)-4-oxo-4H-quinazolin-3-yl]-N-thiazol-2-yl-benzenesulfonamide 
• 65847-33-8 6-(4-nitro-phenyl)-benzo[4,5]imidazo[1,2-c]quinazoline 
• 4765-59-7 2-(4-nitrophenyl)-4(3H)-quinazolinone 
• 36567-86-9 2-(4-nitrophenyl)-3-phenylquinazolin-4(3H)-one 
• 83800-97-9 4-chloro-2-(4-nitrophenyl)quinazoline 

Relevant articles and documents

Synthesis and biological evaluation of certain 3-substituted benzylideneamino-2-(4-nitrophenyl)quinazolin-4(3H)-one derivatives

Certain new 3H-quinazolin-4-one Schiff's bases were synthesized and screened for their activities against ulcerative colitis "UC". Their activity against phospholipase A2 and protease enzymes was also investigated. Some compounds possessed remarkable effe

Direct synthesis of benzoxazinones via Cp*Co(III)-catalyzed C–H activation and annulation of sulfoxonium ylides with dioxazolones

A highly novel and direct synthesis of benzoxazinones was developed via Cp*Co(III)-catalyzed C–H activation and [3 + 3] annulation between sulfoxonium ylides and dioxazolones. The reaction is conducted under base-free conditions and tolerates various functional groups. Starting from diverse readily available sulfoxonium ylides and dioxazolones, a variety of benzoxazinones could be synthesized in one step in 32%-75% yields.

Recyclable Heterogeneous Palladium-Catalyzed Carbonylative Cyclization of 2-Iodoanilines with Aryl Iodides Leading to 2-Arylbenzoxazinones

A highly efficient and practical heterogeneous palladium-catalyzed carbonylative coupling of 2-iodoanilines with aryl iodides has been developed. The reaction occurs smoothly in toluene at 110 °C with N, N -diisopropylethylamine as base under carbon monoxide (5 bar) and offers a general and powerful tool for the construction of various valuable 2-arylbenzoxazinones with excellent atom-economy, high functional group tolerance, good to high yields, and easy recyclability of the palladium catalyst. The reaction is the first example of heterogeneous palladium-catalyzed carbonylative coupling for the preparation of diverse 2-arylbenzoxazinones from commercially easily available 2-iodoanilines and aryl iodides.