777831-40-0

Basic information

• Product Name: 2-nitro-6-<2-(N-benzyl-N-propylaminoethyl)>phenylpyruvic acid
• CAS NO: 777831-40-0
• Molecular Weight: 384.432
• Mol File: 777831-40-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-nitro-6-<2-(N-benzyl-N-propylaminoethyl)>phenylpyruvic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitro-6-<2-(N-benzyl-N-propylaminoethyl)>phenylpyruvic acid(777831-40-0)
• EPA Substance Registry System: 2-nitro-6-<2-(N-benzyl-N-propylaminoethyl)>phenylpyruvic acid(777831-40-0)

Safety Data

• Hazardous Substances Data: 777831-40-0(Hazardous Substances Data)

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 763060-96-4 N-benzyl-N-propyl-2-(2-methyl-3-nitrophenyl)ethylamine 
• 172328-06-2 E conformation of N-benzyl,N-n-propyl (2-methyl-3-nitrophenyl)acetamide 
• 101566-00-1 2-methyl-3-nitrophenylethanoyl chloride 
• 23876-15-5 2-(3-nitro-2-methylphenyl)acetic acid 
• 173990-72-2 ethyl 2-nitro-6-<2-(N-benzy;-N-propylaminoethyl)phenyl>pyruvate 

Downstream Products

• 748747-23-1 2-nitro-6-<2-(N-benzyl-N-propylamino)ethyl>phenylacetic acid 
• 735245-67-7 4-<2-(N-benzyl-N-propylamino)ethyl>-2-indolone 

Relevant articles and documents

A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitors

This paper describes a practical approach to the preparation of 4-(2-hydroxyethyl)indolin-2-one, a key intermediate in the synthesis of dopaminergic agonists such as ropinirole - a drug used in the treatment of Parkinson's disease and restless legs syndrome - and of two sets of protein kinase inhibitors. The sequence starts from commercially available 2-(2-methyl-3-nitrophenyl)acetic acid, which is converted in five steps into the desired target compound. This procedure offers a convenient alternative route to existing methodologies, given its milder reaction conditions, ease of implementation, and its overall yield (59 %).