79513-35-2

Basic information

• Product Name: N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE
• Synonyms: N-T-BOC-1,2-ETHYLENEDIAMINE HCL;N-T-BOC-ETHYLENEDIAMINE HCL;N-TERT-BUTYLOXYCARBONYL-ETHYLENEDIAMINE HYDROCHLORIDE;N-TERT-BUTOXYCARBONYL-ETHYLENEDIAMINE HYDROCHLORIDE;TERT-BUTYL N-(2-AMINOETHYL)CARBAMATE HCL;RARECHEM AR PA 0019;BOC-NH(CH2)2NH2 HCL;BOC-EDA HCL
• CAS NO: 79513-35-2
• Molecular Formula: C₇H₁₆N₂O₂*ClH
• Molecular Weight: 196.68
• Product Categories: Aliphatics;Amines;Cross Linking Reagents
• Mol File: 79513-35-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 148-151°C
• Boiling Point: 252.8 °C at 760 mmHg
• Flash Point: 106.7 °C
• Appearance: /
• Vapor Pressure: 0.019mmHg at 25°C
• Storage Temp.: 2-8°C
• Sensitive: Hygroscopic
• BRN: 3627511
• CAS DataBase Reference: N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE(79513-35-2)
• EPA Substance Registry System: N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE(79513-35-2)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 79513-35-2(Hazardous Substances Data)

Usage

Chemical Properties

nD20 1.458 d 1.012 g/mL Fp >110°C IRRITANT

Uses

N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE is used in the synthesis of Thyronamine derivatives and analogs.

InChI:InChI=1/C7H16N2O2.ClH/c1-7(2,3)11-6(10)9-5-4-8;/h4-5,8H2,1-3H3,(H,9,10);1H

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 57260-73-8 N-BOC-1,2-diaminoethane 
• 96628-67-0 2-(tert-butoxycarbonylamino)ethyl methanesulfonate 
• 26690-80-2 2-(N-tert-butoxycarbonylamino)ethanol 
• 33105-93-0 tert-butyl N-2-[(tert-butoxycarbonyl)amino]ethylcarbamate 
• 117861-38-8 tert-butyl 2-azidoethylcarbamate 
• 333-18-6 1,2-diaminoethane dihydrochloride 

Downstream Products

• 1225189-78-5 5-(3-[(2-tert-butoxycarbonylamino)ethylcarbamoyl]-benzylaminocarboyl)-1,3-dihydropyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione 
• 1225190-09-9 5-(3-[(2-tert-butoxycarbonylamino)ethylcarbamoyl]-benzylaminocarboyl)-9-hydroxy-1,3-dihydropyrrolo[3,4-c]-carbazole-1,3(2H,6H)-dione 
• 152871-77-7 (S)-2-Benzyloxycarbonylamino-4-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-butyric acid 
• 152983-19-2 (R)-2-Benzyloxycarbonylamino-4-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-butyric acid benzyl ester 
• 903881-41-4 (R)-2-Benzyloxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-propionic acid 
• 68027-22-5 2-amino-ethylguanidine dihydrochloride 
• 165196-44-1 tert-butyl (2-acrylamidoethyl)carbamate 
• 864282-43-9 1-[(S)-N-Cbz-2-Amino-3-phenylpropanoyl]-4-(t-butoxycarbonyl)-1,4-diazabutane 
• 875340-78-6 tert-butyl 2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine-2-carboxamido)ethylcarbamate 

Relevant articles and documents

Discovery of Amphamide, a Drug Candidate for the Second Generation of Polyene Antibiotics

Amphotericin B (AmB, 1) is the drug of choice for treating the most serious systemic fungal or protozoan infections. Nevertheless, its application is limited by low solubility in aqueous media and serious side effects such as infusion-related reactions, hemolytic toxicity, and nephrotoxicity. Owing to these limitations, it is essential to search for the polyene derivatives with better chemotherapeutic properties. With the objective of obtaining AmB derivatives with lower self-aggregation and improved solubility, we synthesized a series of amides of AmB bearing an additional basic group in the introduced residue. The screening of antifungal activity in vitro revealed that N-(2-aminoethyl)amide of AmB (amphamide, 6) had superior antifungal activity compared to that of the paternal AmB. Preclinical studies in mice confirmed that compound 6 had a much lower acute toxicity and higher antifungal efficacy in the model of mice candidosis sepsis compared with that of AmB (1). Thus, the discovered amphamide is a promising drug candidate for the second generation of polyene antibiotics and is also prospective for in-depth preclinical and clinical evaluation.

Tmob Side Chain-Protected S-Cysteine- and Homo-S-cysteinesulfonamides, their Nα-Protected and Nω-Aminoethylated Derivatives

The 2,4,6-trimethoxybenzyl (Tmob) group is very suitable for temporary protection of the aminosulfonyl group of S-cysteine- and homo-S-cysteinesulfonamides.Both the introduction and removal of the Tmob-protecting group can be achieved in high yields. 2-Am