81560-03-4

Basic information

• Product Name: 5-bromo-2-methylsulfanyl-3H-pyrimidin-4-one
• Synonyms: 5-bromo-2-methylsulfanyl-3H-pyrimidin-4-one;5-Bromo-2-(methylsulfanyl)-4(1H)-pyrimidinone;5-Bromo-2-(methylsulfanyl...;5-broMo-2-(Methylsulfanyl)-1,4-dihydropyriMidin-4-one;5-bromo-2-(methylsulfanyl)-3,4-dihydropyrimidin-4-one;5-Bromo-2-(methylthio)pyrimidin-4(1H)-one;5-Bromo-2-(methylthio)pyrimidin-4(3H)-one;5-bromo-2-(methylthio)-4(3H)-Pyrimidinone
• CAS NO: 81560-03-4
• Molecular Formula: C₅H₅BrN₂OS
• Molecular Weight: 221.08
• Mol File: 81560-03-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 239 °C (decomp)(Solv: ethanol (64-17-5))
• Boiling Point: 280.4 °C at 760 mmHg
• Flash Point: 123.4 °C
• Appearance: /
• Density: 1.88 g/cm³
• Vapor Pressure: 0.0038mmHg at 25°C
• Refractive Index: 1.697
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 6.03±0.50(Predicted)
• CAS DataBase Reference: 5-bromo-2-methylsulfanyl-3H-pyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-methylsulfanyl-3H-pyrimidin-4-one(81560-03-4)
• EPA Substance Registry System: 5-bromo-2-methylsulfanyl-3H-pyrimidin-4-one(81560-03-4)

Safety Data

• Hazardous Substances Data: 81560-03-4(Hazardous Substances Data)

Usage

General Description

5-bromo-2-methylsulfanyl-3H-pyrimidin-4-one, also known as Bromisoval, is a chemical compound that belongs to the class of pyrimidine derivatives. It is commonly used as a sedative and hypnotic drug, particularly in the treatment of anxiety and insomnia. Bromisoval works by acting as a GABA receptor agonist, enhancing the inhibitory effects of GABA in the central nervous system. This results in sedative and hypnotic effects, making it effective in promoting sleep and reducing anxiety. However, Bromisoval is also known to have potential side effects such as drowsiness, dizziness, and impaired coordination, and therefore should be used with caution and under medical supervision.

InChI:InChI=1/C5H5BrN2OS/c1-10-5-7-2-3(6)4(9)8-5/h2H,1H3,(H,7,8,9)

Upstream product

• 5751-20-2 2-Methylthiouracil 

Downstream Products

• 308276-66-6 tert-butyl 2-(5-bromo-2-(methylthio)-6-oxopyrimidin-1(6H)-yl)acetate 
• 81560-09-0 5-bromo-4-methoxy-2-(methylthio)pyrimidine 
• 571188-81-3 6?bromo?8?cyclopentyl?5?methyl?2?(methylsulfinyl)pyrido[2,3?d]pyrimidin?7(8H)?one 
• 733039-23-1 5?bromo?N?cyclopentyl?2?(methylthio)pyrimidin?4?amine 
• 362656-23-3 8?cyclopentyl?5?methyl?2?(methylthio)pyrido[2,3?d]pyrimidin?7(8H)?one 
• 1378998-71-0 5-bromo-2-[(3,4-dimethoxyphenyl)amino]pyrimidin-4(3H)-one 
• 1378998-80-1 5-bromo-2-[(4-chlorophenyl)amino]pyrimidin-4(3H)-one 
• 1343461-04-0 C₁₃H₁₃BrN₂O₂S 
• 628717-67-9 tert-butyl [5-(4-acetylphenyl)-2-(methylthio)-6-oxopyrimidin-1(6H)-yl]acetate 
• 63810-78-6 4?chloro?5?bromo?2?(methylthio)pyrimidine 
• 81560-06-7 5-bromo-3-methyl-2-(methylthio)pyrimidin-4(3H)-one 
• 26786-28-7 5-bromo-2-phenyl-3H-pyrimidin-4-one 
• 1036763-71-9 3-benzyl-5-bromo-2-(methylthio)pyrimidin-4(3H)-one 

Relevant articles and documents

A Palumbo vial preparation method of the key intermediate (by machine translation)

The invention discloses a Palumbo Xilin key intermediate 6 - bromo - 2 - methyl sulfonyl - 8 - cyclopentyl - 5 - methyl pyridine and (2, 3 - d) pyrimidine - 7 (8 H) - ketone. The method uses the thiourea pyrimidine as the starting material, by methylation, chloro, bromo synthesis of 5 - bromo - 4 - chloro - 2 - methylthio-pyrimidine, then with the cyclopentamine alkylation, with 2 - butenoic acid by the heck reaction, then the intramolecular acylation reaction for the synthesis of 2 - methylthio - 8 - cyclopentyl - 5 - methyl pyridine and (2, 3 - d) pyrimidine - 7 (8 H) - one, finally with the NBS reaction for the preparation of 6 - bromo - 2 - methyl sulfonyl - 8 - cyclopentyl - 5 - methyl pyridine and (2, 3 - d) pyrimidine - 7 (8 H) - one. The preparation process of the present invention short step, not using the dangerous process, simple and convenient operation, low cost of raw materials, to meet the using requirements of the people. (by machine translation)

SUBSTITUTED PYRIMIDINES

The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade

The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.