833480-90-3

Basic information

• Product Name: dantrolene
• Synonyms: dantrolene
• CAS NO: 833480-90-3
• Molecular Weight: 314.257
• Mol File: 833480-90-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: dantrolene(CAS DataBase Reference)
• NIST Chemistry Reference: dantrolene(833480-90-3)
• EPA Substance Registry System: dantrolene(833480-90-3)

Safety Data

• Hazardous Substances Data: 833480-90-3(Hazardous Substances Data)

Upstream product

• 6301-02-6 1-aminohydantoin 
• 7147-77-5 5-(4-nitrophenyl)-2-furaldehyde 
• 2827-56-7 1-aminohydantoin hydrochloride 
• 111-26-2 hexan-1-amine 
• 79-08-3 bromoacetic acid 
• 636-98-6 p-nitrobenzene iodide 

Downstream Products

• 69959-29-1 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione choline salt 

Relevant articles and documents

Dantrolene analogues revisited: General synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle

The general synthesis of dantrolene analogues with various substituents on its phenyl ring has been developed via palladium-catalyzed cross-coupling reactions, the Stille or Suzuki reaction, as the key step. The effects of synthesized analogues have been evaluated by two kinds of Ca2+ release modes from sarcoplasmic reticulum (SR) of mouse skeletal muscle fibers based on: (1) the measurement of twitch contraction caused by the physiological Ca2+ release (PCR) of intact skeletal muscle and (2) the rate of Ca2+-induced Ca2+ release (CICR) in saponin-treated skinned muscle fibers. Although dantrolene, a lead compound, inhibits both twitch contraction and CICR, some structurally modified analogues exhibit one or the other of these effects. The methoxy congener, GIF-0185, potently inhibits the twitch contraction without affecting the CICR, while GIF-0166 and GIF-0248, the ortho-nitro regioisomer and ortho, ortho-dinitro substituted analogues, respectively, doubly potentiate the CICR exclusively.

PACKAGING BAG FOR PLASTER AND PACKAGED PLASTER

Packaged patch (10) according to the invention comprises patch (2) situated in space (4) inside patch package (3) composed of laminated packaging material (1), and its edges are sealed. Laminated packaging material (1) comprises hygroscopic material layer (13) made of LDPE containing 20-40 wt% of an inorganic filler, situated between moisture-permeable material layer (14) made of LDPE and having a moisture permeability of 40-120 g/m2/day and a screen material layer which blocks penetration of moisture, etc. and is composed of HDPE layer (12) and aluminum foil (11). The saturation hygroscopicity of laminated packaging material (1) is 2-30 g/m2under atmosphere conditions with a temperature of 25°C and a relative humidity of 75%. This construction sufficiently reduces the effect of moisture on a drug in patch (2) and allows patch (2) to be held in a stable state for prolonged periods, while also improving the economy and handleability of patch package (3).