835-18-7

Basic information

• Product Name: 3-phenyl-2,3-dihydro-1H-isoindol-1-one
• CAS NO: 835-18-7
• Molecular Formula: C₁₄H₁₁NO
• Molecular Weight: 209.2432
• Mol File: 835-18-7.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 420.2°C at 760 mmHg
• Flash Point: 250.8°C
• Density: 1.194g/cm³
• Vapor Pressure: 2.87E-07mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 3-phenyl-2,3-dihydro-1H-isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-2,3-dihydro-1H-isoindol-1-one(835-18-7)
• EPA Substance Registry System: 3-phenyl-2,3-dihydro-1H-isoindol-1-one(835-18-7)

Safety Data

• Hazardous Substances Data: 835-18-7(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 6637-53-2 3-hydroxy-3-phenyl-2,3-dihydro-isoindol-1-one 
• 85-52-9 2-Benzoylbenzoic acid 
• 88070-48-8 N-methylbenzamide 
• 17599-61-0 N-benzylidene-1,1,1-trimethylsilanamine 
• 57-13-6 urea 
• 30696-82-3 3-Chlor-isoindolin-1-on 
• 71-43-2 benzene 
• 156634-71-8 o-dibromoacetylbenzophenone 
• 574-66-3 Benzophenone oxime 
• 591-51-5 phenyllithium 
• 606-28-0 methyl o-benzoylbenzoate 
• 16780-82-8 2-benzoylbenzaldehyde 
• 550-44-7 N-methylphthalimide 

Downstream Products

• 25365-84-8 3-methoxy-1-phenyl-1H-isoindole 
• 25365-87-1 3-ethoxy-1-phenyl-1H-isoindole 
• 93313-39-4 2-(3-chloropropyl)-3-phenyl-2,3-dihydroisoindolin-1-one 
• 83889-41-2 3-Methoxy-1-phenyl-1H-isoindolium-trifluoromethansulfonat 
• 135127-69-4 3-(4-Nitrophenyl)-isoindolin-1-on 
• 60987-18-0 N-(3-bromopropyl)-3-phenyl-1-isoindolinone 
• 6637-53-2 3-hydroxy-3-phenyl-2,3-dihydro-isoindol-1-one 
• 36149-34-5 2,3-diphenyl-2,3-dihydroisoindol-1-one 
• 1204139-30-9 5-(1H-2,3-dihydro-1-oxo-3-phenylisoindol-2-yl)methylene-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 135412-34-9 3-Methoxy-1-(4-nitrophenyl)-1H-isoindolium-trifluormethansulfonat 
• 86-74-8 9H-carbazole 

Relevant articles and documents

Palladium-catalyzed dehydrogenative C-H cyclization for isoindolinone synthesis

In this paper Pd-catalyzed intramolecular dehydrogenative C(sp3)-H amidation for the synthesis of isoindolinones is described. This method features the use of a Pd/C catalyst and the addition of a stoichiometric amount of oxidant is not necessary. A mechanistic study suggested the possible formation of H2gas during the reaction.

Tropylium-promoted Ritter reactions

The Ritter reaction used to be one of the most powerful synthetic tools to functionalize alcohols and nitriles, providing valuableN-alkyl amide products. However, this reaction has not been frequently used in modern organic synthesis due to its employment of strongly acidic and harsh reaction conditions, which often lead to complicated side reactions. Herein, we report the development of a new method using salts of the tropylium ion to promote the Ritter reaction. This method works well on a range of alcohol and nitrile substrates, giving the corresponding products in good to excellent yields. This reaction protocol is amenable to microwave and continuous flow reactors, offering an attractive opportunity for further applications in organic synthesis.

COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR

The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical compsosition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.