84163-10-0

Basic information

• Product Name: 3-(1-Acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole, 96%
• Synonyms: 3-(1-Acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole, 96%;Ethanone,1-[4-(5-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-;1-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethanone;1-(4-(5-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethanone;1-(4-(5-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethan-1-one
• CAS NO: 84163-10-0
• Molecular Formula: C₁₄H₁₅FN₂O₂
• Molecular Weight: 262.2795032
• Mol File: 84163-10-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 158-159℃
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-(1-Acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole, 96%(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-Acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole, 96%(84163-10-0)
• EPA Substance Registry System: 3-(1-Acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole, 96%(84163-10-0)

Safety Data

• Hazardous Substances Data: 84163-10-0(Hazardous Substances Data)

Usage

Description

3-(1-Acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole, 96% is a chemical compound with the molecular formula C12H12FNO2. It is a derivative of benzisoxazole, a heterocyclic compound with a fused benzene and isoxazole ring. The presence of a 5-fluoro substituent and a 1-acetyl-4-piperidinyl group provides unique chemical and biological properties to this compound.

Uses

Used in Pharmaceutical Industry:
3-(1-Acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole, 96% is used as a reagent in the synthesis of a series of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles. These synthesized compounds exhibit neuroleptic activity, making them potential candidates for the development of drugs targeting neurological disorders and psychiatric conditions.
Used in Chemical Research:
3-(1-Acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole, 96% can also be utilized in chemical research for studying the structure-activity relationships of benzisoxazole derivatives. This knowledge can contribute to the design and development of novel therapeutic agents with improved efficacy and safety profiles.

Upstream product

• 84162-97-0 1-acetyl-4-(5-fluoro-2-hydroxybenzoyl)piperidine oxime 
• 84163-52-0 C₁₆H₁₉FN₂O₄ 

Downstream Products

• 84231-29-8 3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-5-fluoro-1,2-benzisoxazole 
• 84163-16-6 4-(5-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride 

Relevant articles and documents

Synthesis and Neuroleptic Activity of 3-(1-Substituted-4-piperidinyl)-1,2-benzisoxazoles

The synthesis of a series of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles is described.The neuroleptic activity of the series was evaluated by utilizing the climbing mice assay and inhibition of spiroperidol binding.Structure-activity relationships were studied by variation of the substituent on the benzisoxazole ring with concomitant variation of four different 1-piperidinyl substituents.Maximum neuroleptic activity was realized when there was a 6-fluoro substituent on the benzisoxazole ring.The 1-piperidinyl substituent appeared less significant, although in most cases, the (1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl group imparted maximum potency.The most potent compound in both assays was 6-fluoro-3--4-piperidinyl>-1,2-benzisoxazole (11b).