84231-29-8

Basic information

• Product Name: 1,2-Benzisoxazole, 3-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-5-fluoro-
• CAS NO: 84231-29-8
• Molecular Formula: C28H27F3N2O
• Molecular Weight: 464.53
• Mol File: 84231-29-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,2-Benzisoxazole, 3-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-5-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzisoxazole, 3-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-5-fluoro-(84231-29-8)
• EPA Substance Registry System: 1,2-Benzisoxazole, 3-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-5-fluoro-(84231-29-8)

Safety Data

• Hazardous Substances Data: 84231-29-8(Hazardous Substances Data)

Upstream product

• 84163-52-0 C₁₆H₁₉FN₂O₄ 
• 84162-97-0 1-acetyl-4-(5-fluoro-2-hydroxybenzoyl)piperidine oxime 
• 84163-10-0 3-(1-acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole 
• 84163-16-6 4-(5-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride 
• 3312-04-7 4-chloro-1,1-bis(4-fluorophenyl)butane 

Relevant articles and documents

Synthesis and Neuroleptic Activity of 3-(1-Substituted-4-piperidinyl)-1,2-benzisoxazoles

The synthesis of a series of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles is described.The neuroleptic activity of the series was evaluated by utilizing the climbing mice assay and inhibition of spiroperidol binding.Structure-activity relationships were studied by variation of the substituent on the benzisoxazole ring with concomitant variation of four different 1-piperidinyl substituents.Maximum neuroleptic activity was realized when there was a 6-fluoro substituent on the benzisoxazole ring.The 1-piperidinyl substituent appeared less significant, although in most cases, the (1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl group imparted maximum potency.The most potent compound in both assays was 6-fluoro-3--4-piperidinyl>-1,2-benzisoxazole (11b).