84163-16-6

Basic information

• Product Name: 5-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HYDROCHLORIDE
• Synonyms: 1,2-BENZISOXAZOLE, 5-FLUORO-3-(4-PIPERIDINYL)-, MONOHYDROCHLORIDE;5-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HYDROCHLORIDE;5-FLUORO-3-PIPERIDIN-4-YL-1,2-BENZISOXAZOLE HYDROCHLORIDE;5-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazoleHCl;5-Fluoro-3-piperidin-4-yl-1,2-benzisoxazole hydrochloride 97%;5-Fluoro-3-piperidin-4-yl-1,2-benzisoxazolehydrochloride97%;5-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride;5-Fluoro-3-piperidin-4-yl-benzo[d]isoxazole
• CAS NO: 84163-16-6
• Molecular Formula: C₁₂H₁₃FN₂O*ClH
• Molecular Weight: 256.7
• Product Categories: Oxazoles, Isoxazoles & Benzoxazoles;Aromatics;Heterocycles;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 84163-16-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 300-301
• Boiling Point: 359 °C at 760 mmHg
• Flash Point: 170.9 °C
• Appearance: /
• Vapor Pressure: 2.46E-05mmHg at 25°C
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Sensitive: Hygroscopic
• Stability: Hygroscopic
• CAS DataBase Reference: 5-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HYDROCHLORIDE(84163-16-6)
• EPA Substance Registry System: 5-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HYDROCHLORIDE(84163-16-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 84163-16-6(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

An intermediate of 5-Fluoro Risperidone (F595925).

InChI:InChI=1/C12H13FN2O.ClH/c13-9-1-2-11-10(7-9)12(15-16-11)8-3-5-14-6-4-8;/h1-2,7-8,14H,3-6H2;1H

Upstream product

• 84163-52-0 C₁₆H₁₉FN₂O₄ 
• 84163-64-4 5-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 735294-25-4 5-fluorobenzisoxazole 
• 84162-97-0 1-acetyl-4-(5-fluoro-2-hydroxybenzoyl)piperidine oxime 
• 84163-10-0 3-(1-acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole 

Downstream Products

• 84231-29-8 3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-5-fluoro-1,2-benzisoxazole 

Relevant articles and documents

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: Part 2. Pyridazine-based analogs

Design, synthesis, and biological evaluation of pyridazine-based, 4-bicyclic heteroaryl-piperidine derivatives as potent stearoyl-CoA desaturase-1 (SCD1) inhibitors are described. In a chronic study of selected analog (3e) in Zucker fa/fa (ZF) rat, dose-dependent decrease of body weight gain and plasma fatty acid desaturation index (DI) in both C16 and C18 are also demonstrated. The results indicate that the plasma fatty acid DI may serve as an indicator for direct target engagement and biomarker for SCD1 inhibition.

Synthesis and Neuroleptic Activity of 3-(1-Substituted-4-piperidinyl)-1,2-benzisoxazoles

The synthesis of a series of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles is described.The neuroleptic activity of the series was evaluated by utilizing the climbing mice assay and inhibition of spiroperidol binding.Structure-activity relationships were studied by variation of the substituent on the benzisoxazole ring with concomitant variation of four different 1-piperidinyl substituents.Maximum neuroleptic activity was realized when there was a 6-fluoro substituent on the benzisoxazole ring.The 1-piperidinyl substituent appeared less significant, although in most cases, the (1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl group imparted maximum potency.The most potent compound in both assays was 6-fluoro-3--4-piperidinyl>-1,2-benzisoxazole (11b).