847267-25-8

Basic information

• Product Name: Silane, [(5-chloro-2-methoxyphenyl)ethynyl]trimethyl-
• CAS NO: 847267-25-8
• Molecular Formula: C12H15ClOSi
• Molecular Weight: 238.789
• Mol File: 847267-25-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Silane, [(5-chloro-2-methoxyphenyl)ethynyl]trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, [(5-chloro-2-methoxyphenyl)ethynyl]trimethyl-(847267-25-8)
• EPA Substance Registry System: Silane, [(5-chloro-2-methoxyphenyl)ethynyl]trimethyl-(847267-25-8)

Safety Data

• Hazardous Substances Data: 847267-25-8(Hazardous Substances Data)

Upstream product

• 52807-27-9 4-chloro-2-iodo-1-methoxybenzene 
• 1066-54-2 trimethylsilylacetylene 
• 60633-25-2 2-bromo-4-chloroanisole 

Downstream Products

• 1427034-42-1 2-(5-chloro-2-methoxyphenyl)-4-fluoro-1H-indole 
• 1427034-43-2 4-chloro-2-(4-fluoro-1H-indol-2-yl)phenol 
• 1426960-44-2 5-(11-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide 
• 1417516-10-9 C₁₆H₁₃ClO 
• 1242137-84-3 4-chloro-2-[(4-fluorophenyl)ethynyl]-1-methoxybenzene 
• 1191950-69-2 4-chloro-1-methoxy-2-(phenylethynyl)benzene 
• 95186-47-3 4-chloro-2-ethynyl-1-methoxybenzene 

Relevant articles and documents

Synthesis of (Thio)Furan-Fused Phospholes via Phosphonation Cyclization and a Base-Promoted Phospha-Friedel-Crafts Reaction

Herein, we developed a novel strategy for synthesizing ladder (thio)furan-fused phospholes via intermolecular phosphonation cyclization and a base-promoted phospha-Friedel-Crafts reaction under mild conditions. The starting substrates are readily available phosphinic acids and easy-to-handle alkynes. The details of the reaction mechanism were further rationalized using theoretical calculations. This protocol can be widely applied to synthesize furan- and thiofuran-fused phospholes as well as the corresponding large π-extended derivatives, which are of great interest in the domain of organic functional materials.

Practical, modular, and general synthesis of 3-coumaranones through gold-catalyzed intermolecular alkyne oxidation strategy

A gold-catalyzed intermolecular alkyne oxidation for the preparation of 3-coumaranones has been developed. Using 8-isopropylquinoline N-oxides as oxidants, the reactions of o-ethynylanisoles afford versatile 3-coumaranones in moderate to good isolated yields. The synthetic utility of this chemistry is also indicated by the synthesis of the natural product sulfuretin.

TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.