84800-12-4

Basic information

• Product Name: (R)-2-mercapto-3-phenylpropanoic acid
• Synonyms: (R)-2-mercapto-3-phenylpropanoic acid
• CAS NO: 84800-12-4
• Molecular Weight: 182.243
• Mol File: 84800-12-4.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (R)-2-mercapto-3-phenylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-mercapto-3-phenylpropanoic acid(84800-12-4)
• EPA Substance Registry System: (R)-2-mercapto-3-phenylpropanoic acid(84800-12-4)

Safety Data

• Hazardous Substances Data: 84800-12-4(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 26172-50-9 2-ethoxythiocarbonylmercapto-3-phenyl-propionic acid 
• 83080-18-6 C₁₁H₁₄O₂S 
• 103499-59-8 methyl α-mercapto-β-phenylpropionate 
• 62-53-3 aniline 
• 42990-55-6 (S)-(alpha)-bromobenzenepropanoic acid 
• 673-06-3 D-(R)-phenylalanine 
• 63-91-2 L-phenylalanine 
• 35016-63-8 (S)-2-bromo-3-phenylpropionic acid 
• 20312-36-1 L-3-phenyllactic acid 
• 7474-06-8 (S)-2-chloro-3-phenyl-propionic acid 
• 57359-76-9 (2R)-2-(acetylthio)-3-phenylpropanoic acid 
• 103499-63-4 (R)-2-(benzoylthio)-3-phenyl-propanoic acid 

Downstream Products

• 115589-81-6 (2R,4R)-4-Benzyl-2-tert-butyl-[1,3]oxathiolan-5-one 
• 115526-56-2 (2S,5R)-5-benzyl-2-(t-butyl)-1,3-oxathiolan-4-one 
• 736170-70-0 (2S)-3-tert-butoxy-2-[(2R)-2-mercapto-3-phenyl-propionylamino]-propionic acid tert-butyl ester 
• 638142-84-4 1-[5-benzyl-4-oxo-1,3-thiazolidin-2-ylidene]guanidine 
• 1372151-53-5 α-mercapto-β-phenylpropionic acid hydrazide 
• 1372151-68-2 N2-(1-ethoxyethylidene)-α-mercapto-β-phenylpropionic acid hydrazide 

Relevant articles and documents

Inhibition of carboxypeptidase A by (S)-2-mercapto-3-phenylpropanoic acid

(S)-2-Mercapto-3-phenylpropanoic acid is an effective competitive inhibitor of carboxypeptidase A, comparable in potency to (S)-3-mercapto-2-benzylpropanoic acid.

Ruthenium(II)–Arene Thiocarboxylates: Identification of a Stable Dimer Selectively Cytotoxic to Invasive Breast Cancer Cells

RuII-arene complexes provide a versatile scaffold for novel anticancer drugs. Seven new RuII-arene-thiocarboxylato dimers were synthesized and characterized. Three of the complexes (2 a, b and 5) showed promising antiproliferative activities in MDA-MB-231 (human invasive breast cancer) cells, and were further tested in a panel of fifteen cancerous and noncancerous cell lines. Complex 5 showed moderate but remarkably selective activity in MDA-MB-231 cells (IC50=39±4 μm Ru). Real-time proliferation studies showed that 5 induced apoptosis in MDA-MB-231 cells but had no effect in A549 (human lung cancer, epithelial) cells. By contrast, 2 a and b showed moderate antiproliferative activity, but no apoptosis, in either cell line. Selective cytotoxicity of 5 in aggressive, mesenchymal-like MDA-MB-231 cells over many common epithelial cancer cell lines (including noninvasive breast cancer MCF-7) makes it an attractive lead compound for the development of specifically antimetastatic Ru complexes with low systemic toxicity.

Direct synthesis of α-thio aromatic acids from aromatic amino acids

Modified amino acids are useful synthetic components in both chemistry and biology. Here we describe a simple, scalable two-step procedure to generate α-thio aromatic acids from aromatic amino acids with yields of up to 96%. Diazotization and α-lactone me