881674-58-4

Basic information

• Product Name: 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)-
• Synonyms: 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)-;(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol;Vonoprazan Impurity D
• CAS NO: 881674-58-4
• Molecular Formula: C₁₁H₁₀FNO
• Molecular Weight: 191.2016032
• EINECS: -0
• Mol File: 881674-58-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 360.3±32.0 °C(Predicted)
• Appearance: /
• Density: 1.265±0.06 g/cm3(Predicted)
• PKA: 14.48±0.10(Predicted)
• CAS DataBase Reference: 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)-(881674-58-4)
• EPA Substance Registry System: 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)-(881674-58-4)

Safety Data

• Hazardous Substances Data: 881674-58-4(Hazardous Substances Data)

Usage

Uses

5-(2-Fluorophenyl)-1H-pyrrole-3-methanol is an impurity in the preparation of Vonoprazan Fumarate, which acts as a competitive potassium acid blocker.

Upstream product

• 1428932-17-5 2-(2-fluorophenyl)-4-methyl-1H-pyrrole 
• 881673-98-9 ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate 
• 881674-01-7 ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate 
• 881674-06-2 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid ethyl ester 

Downstream Products

• 881674-56-2 5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde 
• 2098974-13-9 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt 
• 881681-00-1 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine 
• 881677-11-8 5‐(2-fluorophenyl)‐1‐(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde 

Relevant articles and documents

Preparation method of vonoprazan fumarate intermediate namely 5-(2-fluorophenyl)-1H-pyrrole-3-methanal

The invention relates to a preparation method of a vonoprazan fumarate intermediate namely 5-(2-fluorophenyl)-1H-pyrrole-3-methanal, and belongs to the technical field of chemical industry. The preparation method comprises the following steps of (1) by using 2-fluoroacetophenone as an initial raw material, enabling the 2-fluoroacetophenone and allylamine to be subjected to condensation so as to obtain a compound IV; (2) under the catalysis of a metal catalyst, and under the condition that a ligand is provided, enabling the compound IV to be subjected to a ring-closing reaction so as to obtain a compound V; and (3) sequentially performing bromination, hydolysis and oxidation reactions by using the compound V so as to obtain the 5-(2-fluorophenyl)-1H-pyrrole-3-methanal. According to the preparation method disclosed by the invention, reagents of bromine, hydrogen chloride and the like, which have strong corrosivity, are prevented from being used, and flammable hydrogenation reducing agents of palladium on carbon, raneys nickel, diisobutylaluminium hydride and the like are also prevented from being used; and besides, the technological line is simple to operate, the reaction condition is mild, the product yield is high, the purity is high, and industrialized production is easy to realize.

Acid secretion inhibitor

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.