887903-03-9

Basic information

• Product Name: 4-fluoro-2-ethynylaniline
• Synonyms: 4-fluoro-2-ethynylaniline
• CAS NO: 887903-03-9
• Molecular Weight: 135.141
• Mol File: 887903-03-9.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 4-fluoro-2-ethynylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluoro-2-ethynylaniline(887903-03-9)
• EPA Substance Registry System: 4-fluoro-2-ethynylaniline(887903-03-9)

Safety Data

• Hazardous Substances Data: 887903-03-9(Hazardous Substances Data)

Upstream product

• 1003-98-1 2-bromo-4-fluoroaniline 
• 61272-76-2 4-fluoro-2-iodoaniline 
• 1066-54-2 trimethylsilylacetylene 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 604797-61-7 5-fluoro-2,3-diphenyl-1H-indole 

Relevant articles and documents

Sequential Sonogashira/intramolecular aminopalladation/cross-coupling ofortho-ethynyl-anilines catalyzed by a single palladium source: rapid access to 2,3-diarylindoles

We have developed a practical and efficient one-pot protocol for the synthesis of 2,3-diarylindolesviaPd-catalyzed bis-arylative cyclization of variouso-ethynylanilines with aryl iodides. Mechanism studies showed that a Pd-catalyzed Sonogashira reaction took place firstly, giving an internal alkyne intermediate, which subsequently underwent intramolecular aminopalladation/cross-coupling to give access to 2,3-diarylindoles. The present methodology exhibits a broad substrate scope, producing various 2,3-diaryl indoles bearing two different aryl groups.

New indolo[1,2-c]quinazolines for single-crystal field-effect transistor: A united experimental and theoretical studies

Here, we account the synthesis and characterization of a series of symmetrical fused heterocyclic aromatic hydrocarbons (HAHs) with an indolo[1,2-c]quinazoline (IQ) as the core moiety. All the new HAHs IQ series were systematically investigated by using various spectroscopic methods. Furthermore, their photo-physical properties were supported by density functional theory (DFT) and time-dependent density functional theory (TDDFT) studies to support the experimental findings. The tetramethyl-substituted indolo[1,2-c]quinazoline (TMIQ) compound is shown to exhibit the shifted type of π–π stacking interactions, which render this series as a new semiconducting material. Single-crystal-based field-effect transistor devices of TMIQ exhibited efficient charge transport behavior, giving a p-channel field-effect mobility of 0.25 cm2?V?1?s?1 with an on/off ratio of 5 × 105.

COMBINATION PRODUCT FOR THE TREATMENT OF CANCEROUS DISEASES

The present invention relates to a product for combination therapies useful for the treatment of cancer diseases. In particular, the invention relates to the combination of an anti-PD-Ll antibody and an MCT4 inhibitor of Formula (I). The therapeutic combination may be utilized for the use in treating a subject having a cancer disease that tests positive for PD-L1 and/or MCT4 expression.