89639-98-5Relevant articles and documents
General synthetic strategies towards N-alkyl sulfoximine building blocks for medicinal chemistry and the use of dimethylsulfoximine as a versatile precursor
Goldberg, Frederick W.,Kettle, Jason G.,Xiong, Jian,Lin, Daoguang
, p. 6613 - 6622 (2015/03/30)
The sulfoximine group has great potential as a substituent in drug discovery, as evidenced by two new clinical candidates, and can be viewed as an isosteric alternative to the commonly used sulfone. Our aim was to improve the accessibility of this group by synthesising a diverse range of S-alkyl and N-alkyl sulfoximine building blocks with procedures that are applicable on a practical scale (>10 g). In particular, synthesis of the less well exploited N-alkyl sulfoximines and the use of dimethylsulfoximine as a versatile, commercially available precursor is discussed.
Carbazole inhibitors of histamine receptors for the treatment of disease
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Page/Page column 72, (2012/01/04)
The present invention relates to carbazole compounds, pharmaceutical compositions comprising them, and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
New selective AT2 receptor ligands encompassing a γ-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists
Rosenstr?m, Ulrika,Sk?ld, Christian,Plouffe, Bianca,Beaudry, Hélène,Lindeberg, Gunnar,Botros, Milad,Nyberg, Fred,Wolf, Gunter,Karlén, Anders,Gallo-Payet, Nicole,Hallberg, Anders
, p. 4009 - 4024 (2007/10/03)
New benzodiazepine-based γ-turn mimetics with one or two amino acid side chains were synthesized. The γ-turn mimetics were incorporated into angiotensin II (Ang II) replacing the Val3-Tyr4-Ile 5 or Tyr4-Ile