91140-23-7Relevant articles and documents
Carbene-catalyzed desymmetrization of 1,3-diols: Access to optically enriched tertiary alkyl chlorides
Li, Bao-Sheng,Wang, Yuhuang,Proctor, Rupert S. J.,Jin, Zhichao,Chi, Yonggui Robin
supporting information, p. 8313 - 8316 (2016/07/06)
The introduction of a chlorine atom to a carbon center in an enantioselective manner via conventional C-Cl bond formation is difficult. Here we report a new approach to this class of tertiary alkyl chlorides with high optical purities. Instead of forming a new C-Cl bond, our approach involves carbene-catalyzed desymmetrization of 2-chloro-1,3-diols as the key step to set up the chiral carbon center with excellent enantiomeric excess.
Ruthenium-catalyzed oxidation of allyl alcohols with intermolecular hydrogen transfer: Synthesis of α,β-unsaturated carbonyl compounds
Ren, Kai,Hu, Bei,Zhao, Mengmeng,Tu, Yahui,Xie, Xiaomin,Zhang, Zhaoguo
, p. 2170 - 2177 (2014/04/03)
Ruthenium-catalyzed oxidation of multisubstituted allyl alcohols in the presence of benzaldehyde gives enals or enones in good yields. Unlike the commonly reported ruthenium-catalyzed isomerization reaction of allyl alcohols to give saturated ketones, an intermolecular rather than intramolecular hydrogen transfer is involved in this transformation. This reaction offers an efficient, mild, and high-yielding method for the preparation of substituted α,β-unsaturated compounds.
Highly enantioselective asymmetric hydrogenation of (E)-β,β- disubstituted α,β-unsaturated Weinreb amides catalyzed by Ir(i) complexes of SpinPhox ligands
Shang, Jian,Han, Zhaobin,Li, Yang,Wang, Zheng,Ding, Kuiling
supporting information; experimental part, p. 5172 - 5174 (2012/06/18)
The Ir(i) complexes of chiral spiro phosphino-oxazoline ligands (SpinPhox) have demonstrated good to excellent enantioselectivity in the asymmetric hydrogenation (AH) of a variety of (E)-β,β-disubstituted α,β-unsaturated N-methoxy-N-methylamides, affording the corresponding optically active Weinreb amides with up to 97% ee.
