928783-85-1Relevant articles and documents
Method for synthesizing 3 -chloro -5 -trifluoromethyltrifluoroacetophenone
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, (2021/11/14)
The invention discloses a method for synthesizing 3 -chloro -5 -trifluoromethyltrifluoroacetophenone, which comprises the following steps: firstly bromination and rechlorination of o-aminotrifluorotoluene to obtain 4 - bromo -2 - chloro -6 - trifluoromethylaniline. 4 - Bromo -2 - chloro -6 - trifluoromethylaniline was subjected to diazotization followed by treatment with hypophosphorous acid or ethanol to give the deamination compound 1 - bromo -3 - chloro -5 - (trifluoromethyl) benzene. 1 - Bromo -3 - chloro -5 - (trifluoromethyl) benzene was made into Grignard reagent with magnesium chips and reacted with the acylating agent to give 3 - chloro -5 - trifluoromethyltrifluoroacetophenone. The starting material ortho-aminotrifluorotoluene used in the route is a common chemical with cheap price, and the obtained product is high in purity and yield, relatively small in environmental pollution and expected to be used for large-scale industrial production.