94061-83-3

Basic information

• Product Name: FLUVASTATIN LACTONE
• Synonyms: FLUVASTATIN LACTONE;(4R,6S)-6-[(1E)-2-[3-(4-Fluorophenyl)-1-(1-Methylethyl)-1H-indol-2-yl]ethenyl]tetrahydro-4-hydroxy-2H-Pyran-2-one
• CAS NO: 94061-83-3
• Molecular Formula: C₂₄H₂₄FNO₃
• Molecular Weight: 423.4335832
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 94061-83-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 55-63°C
• Appearance: /
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: FLUVASTATIN LACTONE(CAS DataBase Reference)
• NIST Chemistry Reference: FLUVASTATIN LACTONE(94061-83-3)
• EPA Substance Registry System: FLUVASTATIN LACTONE(94061-83-3)

Safety Data

• Hazardous Substances Data: 94061-83-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

A synthetic HMG-CoA reductase inhibitor.

Upstream product

• 155229-75-7 fluvastatin 
• 93957-54-1 fluvastatin 
• 94061-80-0 fluvastatin sodium 

Downstream Products

• 1217796-99-0 tetraethyl N-(((3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoyl)aminomethylenebisphosphonate 
• 1352078-35-3 C₂₄H₂₆FNO₃ 
• 109856-13-5 cis-6-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-3,6-dihydro-2H-pyran-2-acetic acid 
• 109856-14-6 7-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-2,4,6-heptatrienoic acid 

Relevant articles and documents

Multi-substituted indoles lactone dehydration compound and use thereof

The invention provides a compound, belonging to the field of medicinal chemistry. A structural formula of the compound is described in the specification. According to a test, the compound has the effects of restraining the activity of HMG-coA reductase, and can be used as a new-generation potential HMG-coA reductase inhibitor.

Synthesis and hydroxyapatite binding activity of bisphosphonate-statin conjugates

To develop a methodology for delivering anabolic agents statins to bone, a bone targeting bisphosphonate was used as a carrier of drugs. Four statin-bisphosphonate conjugates were synthesized and examined for their bone mineral affinity in vitro by hydrox