- l-Methadone
- l-Methadone hydrochloride
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Cas Database |
| Name |
l-Methadone hydrochloride |
EINECS | N/A |
| CAS No. | 5967-73-7 | Density | N/A |
| PSA | 20.31000 | LogP | 5.09400 |
| Solubility | N/A | Melting Point |
220-227°C |
| Formula | C21H27 N O . Cl H | Boiling Point | 423.7°C at 760 mmHg |
| Molecular Weight | 345.912 | Flash Point | 126.5°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intravenous, subcutaneous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations, distorted perceptions, and analgesia. Caution: Abuse leads to habituation or addiction. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also METHADONE HYDROCHLORIDE. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
3-Heptanone,6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (-)- (8CI); 3-Heptanone,6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (6R)- (9CI); 3-Heptanone,6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (R)-; (-)-Methadonehydrochloride; D-(-)-Methadone hydrochloride; Levomethadone hydrochloride;Levorotatory methadone hydrochloride;l-6-Dimethylamino-4,4-diphenyl-3-heptanone hydrochloride; l-Methadonehydrochloride; l-Polamidon hydrochloride |
Article Data | 5 |
l-Methadone hydrochloride Chemical Properties
IUPAC Name: (6R)-6-(Dimethylamino)-4,4-diphenylheptan-3-one hydrochloride
Synonyms: (-)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone Hydrochloride ; (R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone Hydrochloride ; Levadone ; L-Polamidon
CAS NO: 5967-73-7
Molecular Formula of l-Methadone hydrochloride (CAS NO.5967-73-7) :C21H28ClNO
Molecular Weight of l-Methadone hydrochloride (CAS NO.5967-73-7) : 345.
90612
Molecular Structure of l-Methadone hydrochloride (CAS NO.5967-73-7) :
EINECS: 227-756-6
Mol File: 5967-73-7.mol
Flash Point: 126.5 °C
Enthalpy of Vaporization: 67.8 kJ/mol
Boiling Point: 423.7 °C at 760 mmHg
Vapour Pressure: 2.2E-07 mmHg at 25°C
l-Methadone hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | oral | 44ug/kg (0.044mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: ANALGESIA | Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 282, 1948. |
| mouse | LD50 | intraperitoneal | 30mg/kg (30mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 98, Pg. 305, 1950. | |
| mouse | LD50 | intravenous | 18mg/kg (18mg/kg) | BEHAVIORAL: ANALGESIA | Acta Physiologica Academiae Scientiarum Hungaricae. Vol. 4, Pg. 363, 1953. |
| mouse | LD50 | oral | 97300ug/kg (97.3mg/kg) | Journal of Organic Chemistry. Vol. 17, Pg. 321, 1952. | |
| mouse | LD50 | parenteral | 6483ug/kg (6.483mg/kg) | BEHAVIORAL: ANALGESIA | Journal of Pharmacology and Experimental Therapeutics. Vol. 145, Pg. 11, 1964. |
| mouse | LD50 | subcutaneous | 19mg/kg (19mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 98, Pg. 305, 1950. | |
| rat | LD50 | intraperitoneal | 24mg/kg (24mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 98, Pg. 305, 1950. | |
| rat | LD50 | subcutaneous | 20mg/kg (20mg/kg) | ENDOCRINE: OTHER CHANGES | British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 260, 1955. |
l-Methadone hydrochloride Safety Profile
Poison by intravenous, subcutaneous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations, distorted perceptions, and analgesia. Caution: Abuse leads to habituation or addiction. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also METHADONE HYDROCHLORIDE.
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