Role of ISOSAFROLE (cas 120-58-1) as complexing agent and inducer of P-450LM4 in rabbit liver microsomes
-
Add time:09/04/2019 Source:sciencedirect.com
ISOSAFROLE (cas 120-58-1) serves as an excellent inducing agent in rabbits for P-450LM4, the same isozyme as that which is induced by 3-methylcholanthrene and 5,6-benzoflavone. Since the isosafrole adduct formed with isozyme 4 is unstable, the uncomplexed cytochrome may be purified in very good yield (over 30%, based on total P-450) from liver microsomes of animals given this agent. Isosafrole forms adducts with both isozyme 2 (the phenobarbital-inducible form of P-450) and isozyme 4 in the reconstituted system containing NADPH-cytochrome P-450 reductase, phosphatidylcholine, and NADPH under aerobic conditions, but with the latter cytochrome the reaction has a lower Km and maximal rate.
We also recommend Trading Suppliers and Manufacturers of ISOSAFROLE (cas 120-58-1). Pls Click Website Link as below: cas 120-58-1 suppliers
Prev:Interactions of safrole and ISOSAFROLE (cas 120-58-1) and their metabolites with cytochromes P-450
Next:Oxidation of ISOSAFROLE (cas 120-58-1) by sodium hypochlorite catalysed by manganese porphyrins: Unusual competition between epoxidation and O-dealkylation) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Further studies on the dissociation of the ISOSAFROLE (cas 120-58-1) metabolite-cytochrome p-450 complex09/06/2019
- Oxidation of ISOSAFROLE (cas 120-58-1) by sodium hypochlorite catalysed by manganese porphyrins: Unusual competition between epoxidation and O-dealkylation09/05/2019
- Interactions of safrole and ISOSAFROLE (cas 120-58-1) and their metabolites with cytochromes P-45009/03/2019
- Rapid CommunicationInduction of cytochrome p-450 in congenic c57bl/6j mice by ISOSAFROLE (cas 120-58-1): lack of correlation with the ah locus09/02/2019
- Catalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with β-naphthoflavone or ISOSAFROLE (cas 120-58-1)09/01/2019
- Research paperDistinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and ISOSAFROLE (cas 120-58-1)08/31/2019
- Solvent and support electrolyte effects on the catalytic activity of Ti/RuO2 and Ti/IrO2 electrodes: oxidation of ISOSAFROLE (cas 120-58-1) as a probe model08/30/2019
- The conversion of ISOSAFROLE (cas 120-58-1) to piperonal and anethole to anisaldehyde: electrochemical active manganese dioxide08/29/2019
- Chemical markers from the peracid oxidation of ISOSAFROLE (cas 120-58-1)08/28/2019