Further studies on the dissociation of the ISOSAFROLE (cas 120-58-1) metabolite-cytochrome p-450 complex
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Add time:09/06/2019 Source:sciencedirect.com
The dissociation of an in vivo ISOSAFROLE (cas 120-58-1) metabolite-cytochrome P-450 complex by a number of exogenous and endogenous compounds is described. The rate of dissociation is temperature-dependent, but the process does not require oxygen. Compounds which produce Type I (substrate) binding spectra with oxidized cytochrome P-450 facilitate displacement of the isosafrole metabolite from cytochrome P-450 whereas Type II (ligand-binding) compounds do not dissociate the complex. The factors necessary for dissociation of the complex are discussed and a model for the isosafrole metabolite-cytochrome P-450 complex is proposed.
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