- Preparation of 3-substituted-2-pyridin-2-ylindoles: regioselectivity of Larock's indole annulation with 2-alkynylpyridines
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A regioselective Larock approach to 3-substituted-2-pyridin-2-ylindoles from 2-alkynylpyridines and 2-iodoanilines is described herein. The unexpectedly high regioselectivity can be rationalized by a combination of steric, coordinative and electronic effects.
- Roschangar, Frank,Liu, Jianxiu,Estanove, Emilie,Dufour, Marine,Rodríguez, Sonia,Farina, Vittorio,Hickey, Eugene,Hossain, Azad,Jones, Paul-James,Lee, Heewon,Lu, Bruce Z.,Varsolona, Richard,Schr?der, Jürgen,Beaulieu, Pierre,Gillard, James,Senanayake, Chris H.
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p. 363 - 366
(2008/09/17)
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- NOVEL MCH RECEPTOR ANTAGONISTS
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The present invention relates to a melanin concentrating hormone antagonist compound of formula I: or a pharmaceutically acceptable salt thereof, useful for the treamtment useful fog treating Type H diabetes and/or obesity.
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Page/Page column 68
(2010/02/11)
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- 1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO
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Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
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Page/Page column 189
(2010/02/11)
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- VIRAL POLYMERASE INHIBITORS
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An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.
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- Stereoselective synthesis of (E)-3-(methoxycarbonyl)methylene-1,3-dihydroindol-2-ones by palladium-catalyzed oxidative carbonylation of 2-ethynylanilines
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A direct synthesis of (E)-3-(methoxycarbonyl)methylene-1,3-dihydroindol-2-ones 2 by palladium-catalyzed oxidative carbonylation of 2-ethynylanilines 1 is reported. Reactions were carried out in MeOH as the solvent at 50-70°C in the presence of catalytic a
- Gabriele, Bartolo,Salerno, Giuseppe,Veltri, Lucia,Costa, Mirco,Massera, Chiara
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p. 4607 - 4613
(2007/10/03)
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- The solid phase synthesis of tri-substituted indoles
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The palladium-catalyzed solid phase synthesis of tri-substituted indoles is described. The synthesis incorporates three independently variable groups and is ideally suited for the preparation of combinatorial libraries.
- Collini, Michael D.,Ellingboe, John W.
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p. 7963 - 7966
(2007/10/03)
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